Tomographic and histological analysis of different approaches for closing the tooth extraction space: a study in humans

Clinical and histological analysis of the socket sealing with Bio-Gide® versus Mucograft® of post-extraction sockets filled with Bio-Oss® Collagen: a study in humans

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

REBEC

Registry ID

RBR-10nbmqm8

Enrollment

Unknown

Registered

2021-05-07

Start date

2015-09-14

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth socket.

Interventions

After local anesthesia with 2% mepivacaine with epinephrine 1:100,000, flapless extractions were performed as gentle as possible with periotome and a vertical root extractor. Extraction sockets were c

2. Collagen matrix (Mucograft Seal, Geistlich Pharma AG) - 5 participants

3. Collagen membrane (Bio-Gide, Geistlich Pharma AG) - 5 participants

4. Autogenous graft (soft tissue punch graft from the palate) - 6 participants.

E04.545.700

E06.645.550.100

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 18 years-old or above; at least 20 teeth in mouth; satisfactory oral hygiene (plaque index = 25%); tooth with extraction indication in maxillary aesthetic zone (non-molar region); both adjacent teeth for interproximal bone crest maintenance; integrity of the alveolar bone around the tooth (no bone loss in any socket wall) assessed by cone beam computed tomography (CBCT) and confirmed by post-extraction clinical examination.

Exclusion criteria

Exclusion criteria: Smokers; patients with self-reported systemic conditions such as uncontrolled diabetes and pregnancy.

Design outcomes

Secondary

Measure	Time frame
Evaluation of the cross-sectional area of the alveolar ridge, using the tomographic analysis, taking into consideration the variation between the exams carried out before tooth extraction and after 4 to 6 months;Evaluation of the thickness of the bone ridge, using the tomographic analysis, taking into consideration the variation between the exams carried out before tooth extraction and after 4 to 6 months	—

Measure

Time frame

Evaluation of the cross-sectional area of the alveolar ridge, using the tomographic analysis, taking into consideration the variation between the exams carried out before tooth extraction and after 4 to 6 months;Evaluation of the thickness of the bone ridge, using the tomographic analysis, taking into consideration the variation between the exams carried out before tooth extraction and after 4 to 6 months

—

Primary

Measure	Time frame
Evaluation of the height of the buccal bone wall, using the tomographic analysis, taking into consideration the variation between the exams carried out before tooth extraction and after 4 to 6 months;Evaluation of the height of the palatal bone wall, using the tomographic analysis, taking into consideration the variation between the exams carried out before tooth extraction and after 4 to 6 months	—

Measure

Time frame

Evaluation of the height of the buccal bone wall, using the tomographic analysis, taking into consideration the variation between the exams carried out before tooth extraction and after 4 to 6 months;Evaluation of the height of the palatal bone wall, using the tomographic analysis, taking into consideration the variation between the exams carried out before tooth extraction and after 4 to 6 months

—

Countries

Austria, Brazil

Contacts

Public ContactCesar Benfatti

cesarbenfatti@yahoo.com+55 48 9922-9961

Outcome results

None listed

Source: REBEC (via WHO ICTRP)