Periodontal Diseases
Conditions
Interventions
This is a split-mouth, triple-blind, randomized controlled clinical study. Participants will have their periodontal clinical parameters (plaque index, gingival index, probing depth, gingival recession
Red laser photobiomodulation (PBMV): Photobiomodulation will be performed with a red laser (660 nm) in 20 sites using a Duo? laser with the optical fiber inside the periodontal pocket in back and fort
Photobiomodulation with infrared laser (PBMIV): Photobiomodulation will be performed with an infrared laser (808 nm) in 20 sites using a Duo? laser with the optical fiber inside the periodontal pocket
Sponsors
Universidade Federal Fluminense - Polo de Nova Friburgo
Universidade Federal Fluminense - Polo de Nova Friburgo
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers; both genders; aged between 18 and 70 years; with four or more periodontal sites with probing depth greater than or equal to 6 millimeters and clinical attachment level grater then or equal to 5 millimeters non-adjacent
Exclusion criteria
Exclusion criteria: Hypersensitivity to the components of 0.005 percent methylene blue gel; patients who received periodontal treatment in the last six months; use of medications as anti-inflammatories and antibiotics in the last 3 months; any evidence of systemic modifying factors that may directly interfere as bias, such as: pregnant and breastfeeding women, on hormone replacement therapy, smokers, diagnosed with hyperglycemia and diabetes, osteoporosis; with HIV+ or AIDS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the impact of different treatments on the periodontal clinical parameter probing depth, given in millimeters, measured at the initial time and after 3 months of treatment, using the periodontal probing method with the use of a PCP15UNC periodontal probe (Hu-Friedy, Chicago, IL , USA).;To evaluate the impact of different treatments on the periodontal clinical parameter clinical level of attachment, given in millimeters, measured at the initial time and after 3 months of treatment, using the periodontal probing method using a PCP15UNC periodontal probe (Hu-Friedy, Chicago, IL, USA). | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the presence of periodontal pathogens in biofilms in the gingival fluid of four sites with probing depth =6 mm before and after treatments. Samples will be collected at selected locations and stored in eppendorfs with 1X PBS at -20oC and evaluated using DNA extraction, electrophoresis and qualitative polymerase chain reaction (PCR) methods.;To evaluate the periodontal clinical parameter plaque index, given as a percentage, measured at the initial time and after 3 months of treatment, using the method described by Ainamo and Bay (1975).;Evaluate the periodontal clinical parameter gingival index, given in percentage, measured at the initial time and after 3 months of treatment, using the method described by Ainamo and Bay (1975).;To evaluate the periodontal clinical parameter gingival recession, given in millimeters, measured at the initial time and after 3 months of treatment, using the periodontal probing method using a PCP15UNC periodontal probe (Hu-Friedy, Chicago, IL, USA). | — |
Countries
Brazil
Contacts
Public ContactRaquel Carmo
Universidade Federal Fluminense
Outcome results
None listed