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Effect of pH of Whitening Gels on color change and sensitivity in patients with aesthetic restorations

The effect of Hydrogen Peroxide Gel pH on the effectiveness and sensitivity of in-office bleaching in patients with aesthetic restorations: a randomized clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-10mw2696
Enrollment
70
Registered
2026-07-21
Start date
2026-04-20
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin Sensitivity

Interventions

This is a randomized, two-arm, single-blind clinical trial. Seventy eligible participants will be recruited and randomly allocated into two groups (n = 35) using a randomization sequence generated fro

Sponsors

Universidade Federal do Ceará
Lead Sponsor
Universidade Federal do Ceará
Collaborator
Hospital Universitário Walter Cantídio da Universidade Federal do Ceará - HUWC/UFC
Collaborator

Eligibility

Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers of both sexes; aged between 18 and 50 years; presence of all six upper anterior teeth; upper canines should be A2 or darker in color compared to the Vita Classical visual color scale; presence of at least two Class III restorations in the upper anterior teeth; the restorations should not involve more than 1/4 of the vestibular surface and should not be located in a way that interferes with the spectrophotometer placement

Exclusion criteria

Exclusion criteria: Volunteers with severely pigmented teeth (tetracycline stains and fluorosis); pregnant or breastfeeding women; smokers; patients undergoing orthodontic treatment; patients with endodontic treatment and unsatisfactory restorations (presence of secondary caries, cracks, and marginal infiltration) in any of the six upper anterior teeth; volunteers undergoing treatment with anti-inflammatory, analgesic, and/or antioxidant medications; volunteers with gingival recession and/or tooth wear with dentin exposure; patients who have undergone previous whitening treatments within the last 12 months

Design outcomes

Primary

MeasureTime frame
To compare, through a randomized clinical trial, the whitening efficacy and dentin sensitivity of in-office dental whitening performed with 35% hydrogen peroxide at different pH levels in patients with previous aesthetic restorations

Secondary

MeasureTime frame
To compare the effectiveness, 1 week after each session and 30 days and 6 months after the end of treatment, of in-office whitening with hydrogen peroxide gels with acidic or neutral/alkaline pH;Measure the level of sensitivity to in-office whitening with hydrogen peroxide gels with acidic or alkaline pH;Evaluate the patients' aesthetic self-perception before and after treatment;Evaluate the impact of whitening on oral health-related quality of life before and after treatment

Countries

BR

Contacts

Public ContactVanara Passos

Universidade Federal do Ceará

vanarapassos@hotmail.com+55-85-33668232

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026