Periodontal Diseases
Conditions
Interventions
The study will be conducted as a randomized, split-mouth, double-blind clinical trial in patients with stage II or stage III periodontitis with at least 12 teeth in the oral cavity. Fifteen patients w
patients will not be informed which hemiarch received each treatment
the gels will be manipulated with similar visual and consistency characteristics, allowing application without spontaneous identification of the products
laboratory samples will be coded with numerical identification, ensuring that the professional responsible for the analyses also remains blind to the experimental group. The Plaque Index (PI), Bleedin
Sponsors
Centro de Ciências Biológicas e da Saúde - CCBS - Universidade Estadual do Oeste do Paraná - UNIOESTE
Universidade Estadual do Oeste do Paraná
Eligibility
Age
25 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 25 and 65 years. Both sexes. Presence of at least 12 teeth in the oral cavity, with at least 3 elements per hemiarch (excluding third molars). Diagnosis of Stage II or III Grade A periodontitis (bilateral periodontal pockets with Clinical Attachment Level (CAL) greater than or equal to 5mm)
Exclusion criteria
Exclusion criteria: Completely edentulous individuals. Pregnant and breastfeeding women. Regular use (for 14 days or more) of antibiotics, anti-inflammatories, and immunosuppressants. Wearing fixed orthodontic appliances. Smokers. Presence of systemic alterations. Undergoing treatment for neoplasms
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study aims to demonstrate the effect of using ozonized oil gel compared to using 1% chlorhexidine gel in the treatment of patients with stage II or stage III periodontitis, evaluating clinical parameters such as Plaque Index (PI), Bleeding on Probing (BOP), Probing Depth (PD), and Clinical Attachment Level (CAL), through statistical analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| The aim is to evaluate whether ozonized oil gel associated with basic periodontal treatment will improve periodontal clinical parameters, as well as inflammation and growth factors in patients with stage II or III periodontitis, by measuring Transforming Growth Factor Beta 1 (TGF-ß1) using the ELISA test, and quantifying absorbed Gingival Crevicular Fluid (GCF) in square millimeters using software. | — |
Countries
Brazil
Contacts
Public ContactDébora Regelin
Universidade Estadual do Oeste do Paraná
Outcome results
None listed