FindTrial
Sign In

Evaluation of vaginal flora, hormonal cytology, and vaginal biopsy in menopausal women comparing the use of non-ablative radiofrequency, CO2 laser, and vaginal estrogen

Evaluation of the vaginal microbiome, hormonal citology and vaginal histology in postmenopausal women following non-ablative radiofrequency, CO2 laser therapy, and vaginal estrogen

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-10mng9xp
Enrollment
Unknown
Registered
2026-01-30
Start date
2026-02-27
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Estrogen replacement therapy

Interventions

This is a randomized, non-blinded clinical trial to be conducted in a tertiary maternity hospital in the state of Ceará with menopausal women with genitourinary syndrome of menopause. Patients will be
s climacteric outpatient clinic and will be randomized into one of three study groups through simple randomization. There will be two intervention groups: one with 20 patients who will receive CO2 las

Sponsors

Maternidade Escola Assis Chateaubriand / MEAC ( maternidade escola Assis Chateaubriand)/ UFC( universidade federal do Ceará)
Lead Sponsor
Maternidade Escola Assis Chateaubriand / MEAC ( maternidade escola Assis Chateaubriand)/ UFC( universidade federal do Ceará)
Collaborator

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Healthy menopausal women; with or without an active sex life; complaints related to genitourinary atrophy

Exclusion criteria

Exclusion criteria: Oncotic cytology with atypical cells precursors to cervical cancer; use of hormone therapy in the last 6 months (topical or systemic); use of vaginal lubricants or moisturizers in the last month; active genital infections

Design outcomes

Primary

MeasureTime frame
Improvements in pH (decrease), microbiome (increase in lactobacilli), hormonal cytology (improvement in maturation index), and increased vaginal tissue thickness are expected in menopausal women after the use of microablative radiofrequency and CO2 laser, compared to vaginal estrogen—

Secondary

MeasureTime frame
An improvement in the FSFI (female sexual function index) is expected in menopausal women after the use of microablative radiofrequency and CO2 laser, compared to vaginal estrogen—

Countries

Brazil

Contacts

Public ContactCristiana Teófilo

Universidade Federal do Ceará

crisrt@gmail.com+5585988831774

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 7, 2026