Evaluation of the use of Membranes incorporated with Ozonized Oil in the healing of Extraction Surgery of lower third molar teeth: randomized, split-mouth, prospective, double-blind clinical trial

Evaluation of the use of Nanofibers incorporated with Ozonized Oil in the healing of lower third molar extractions: randomized, split-mouth, prospective, double-blind clinical trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

REBEC

Registry ID

RBR-10mc9dwz

Enrollment

Unknown

Registered

2024-04-03

Start date

2024-06-15

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wound Healing

Interventions

This will be a randomized, prospective, double-blind, split mouth clinical study, in which the patient and evaluator will be blinded to the distribution of the groups. 36 patients aged 18 to 59 years

Negative Control (CN) x White Control 2 (CB2)

Negative Control (CN) x Treatment (T)

White Control 1 (CB1) x White Control 2 (CB2)

White Control 1 (CB1) x Treatment (T)

White Control 2 (CB2) x Treatment (T). The distribution of the group to be assigned for the first time will be recorded sequentially on numbered cards and placed in sealed envelopes. The information c

white control 1 will receive, in addition to the suture, the electrospun nanofiber membrane without additives

white control 2 will receive the suture and nanofiber membrane electrospun with fresh sunflower oil

and the treatment will include suture and nanofiber membrane electrospun with ozonized sunflower oil. Once the participant is eligible for the procedure and all assessments are completed, the allocati

MT3.465.599

E06.892

Eligibility

Age

18 Years to 59 Years

Inclusion criteria

Inclusion criteria: Adult patients aged 18 to 59 years; of both sexes; without problems systemic; with semi-retained teeth 38 and 48 indicated for extraction

Exclusion criteria

Exclusion criteria: Patients with fully erupted lower third molars; patients with diseases such as hypertension; diabetes and syndromes; pregnant patients; patients with diagnosis of platelet problems; smokers or alcoholics; patients under 18 years of age and over 59 years of age

Design outcomes

Primary

Measure	Time frame
To verify the success of using a polymer as a molecule to accelerate the post-surgical healing process of patients belonging to the group that will receive the synthesis of surgery with suture + nanofiber membrane electrospun with ozonized sunflower oil.	—

Secondary

Measure	Time frame
Evaluate the healing process in the immediate postoperative period, 3 days, 7 days, 14 days and 21 days, of the different treatments and the negative control group (untreated) through clinical measurement of the wounds.	—

Countries

Brazil

Contacts

Public ContactBrenda Rex Machado

Universidade Estadual do Oeste do Paraná

bre.rex@hotmail.com+55(45)99985-8553

Outcome results

None listed

Source: REBEC (via WHO ICTRP)