chronic periodontitis
Conditions
Interventions
Randomized 3-arm, double-blind, clinical trial. The sample will be randomly assigned by the Excel software in 3 groups, according with the type of acid conitioning. Each group will be composed of 17 p
at Group AC (citric acid), infraosseous defecs wll be demineralized by the application of 10% citric acid gel solution, pH 1, for 15 seconds, filled with particulated non-demineralized xenograft and c
at group TCN (hydrochloride tetracycline), infraosseous defects will be demineralized by hydrochloride tetracycline solution. at the concentration of 50 mg/ml, pH 1,3, for 60 seconds, filled with part
D02.455.426.559.847.562.900.875
Sponsors
Universidade de São Paulo, Faculdade de Odontologia de Bauru
Universidade de São Paulo, Faculdade de Odontologia de Bauru
Eligibility
Age
35 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age 35 - 60 years; radiographic evidence of at least one infrabony 2 or 3-wall or combined interproximal periodontal defect; attachment loss = 5 mm
Exclusion criteria
Exclusion criteria: Systemic disorders (uncontrolled diabetes and hypertension, hemophilia or other coagulation disordes); pregnants or lactants; systemic therapy with antimicrobials, antineoplastics, anticoagulants, immunostimulants or immunodepressors 4 weeks before study beggining; radiotherapy and/or immunosupression; endodontic lesions; grade 2 tooth mobility; severe parafunction; allergy to citric acid and/or tetracycline; illicit drugs or alcohol abusers; smokers or former smokers < 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to observe pocket depth at 12-month post-operative examination, as determined by the measurement of the distance from gingival margin to the bottom of the sulcus or pocket with a millimeter periodontal probe (UNC-15) by a single blinded and calibrated examiner;It is expected to observe attachment gain at 12-month post-operative examination, as determined by the measurement of the distance from cementum-enamel junction to the bottom of the sulcus or pocket with a millimeter periodontal probe (UNC-15) by a single blinded and calibrated examiner;It is expected to observe radiographic bone filling at 12-month post-operative examination, as determined in intra-oral X-ray images as the distance from the most apical point of cementum-enamel junction to the base of the defect | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to observe radiographic integrity of lamina dura at 12-month post-operative examination, as determined in intra-oral X-ray images as a radiopaque continuous line through the lateral aspect of the roots | — |
Countries
Brazil
Contacts
Public ContactAdriana Sant'Ana
Universidade de São Paulo, Faculdade de Odontologia de Bauru
Outcome results
None listed