Coronavirus
Conditions
Interventions
This is an open-label, non-randomized, three-arm clinical trial. 192 volunteers, 96 men and 96 women, aged between 30 and 55 years, who were affected by Covid-19, will be studied. The volunteers will
N=64) and asymptomatic group (Control group
N=64). All volunteers will be evaluated at the beginning of the experimental protocol and after 16 weeks of aerobic training on an ergometric bicycle, with three sessions a week and duration of 60 min
complete blood count
lipid profile, hemodynamic values
cardiorespiratory fitness
cardiovascular autonomic control through baroreflex sensitivity and analysis of heart rate and blood pressure variability.
E02.760.169.063.500.387
Sponsors
Faculdade de Medicina de Ribeirão Preto
Universidade de Franca - Unifran
Eligibility
Age
30 Years to 55 Years
Inclusion criteria
Inclusion criteria: Men and women; aged between 30 and 55 years; affected by Covid-19 in the mild form of the disease (treated at home); and in the severe form of the disease (required hospitalization); individuals who present any symptoms of the disease such as dyspnea; fatigue; respiratory and/or skeletal muscle weakness; among others.
Exclusion criteria
Exclusion criteria: Men and women who are in the period of transmission of the Covid-19 disease or who are undergoing previous home or outpatient physical therapy treatment; individuals with a cognitive disorder that prevents them from understanding the tests and training; musculoskeletal changes that make it impossible to perform tests and aerobic physical training; hemodynamic instability or that evolved with arrhythmias; smokers or who use drugs that interfere with cardiac functionality and cardiovascular autonomic control.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Healthy men and women, without previous disease, affected by Covid-19, who developed the mild, moderate or severe form of the disease, may present increased sympathetic influence and decreased parasympathetic activity when evaluated through spectral analysis of heart rate and compared conditions. pre and post the aerobic physical training program.;It is expected to find metabolic alterations, evaluated through blood samples, such as: increase in fasting glucose and insulin; increase in total cholesterol and fractions; increase in triglycerides; increase in C-reactive creatine; increased levels of tumor necrosis and interleukins (IL-6 and IL-10). All these variables are influenced by the aerobic physical training program. | — |
Secondary
| Measure | Time frame |
|---|---|
| The aerobic physical training program may be able to promote in all men affected by covid-19, from the three groups studied, the improvement of cardiorespiratory and metabolic function, such as the anaerobic threshold and volume of oxygen consumed at peak exercise (VO2peak) , evaluated by means of the ergospirometric test.;The aerobic physical training program may also be able to promote different cardiac hemodynamic and autonomic effects, decrease inflammatory markers, in addition to improving skeletal muscle strength and functionality, which may provide benefits for physical and mental health. | — |
Countries
Brazil
Contacts
Public ContactHugo;Tábata Souza;Facioli
Faculdade de Medicina de Ribeirão Preto - FMRP/USP;Faculdade de Medicina de Ribeirão Preto - FMRP/USP
Outcome results
None listed