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Effects of Breaks Sedentary Behavior with unsupervised Isometric Exercise in Sedentary adults

Effects of Breaks from Sedentary Behavior with unsupervised Isometric Exercise on Vascular Function, Blood Pressure and Cardiac Autonomic Modulation in Sedentary adults: Randomized Controlled Clinical Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-10k2wxrg
Enrollment
Unknown
Registered
2023-03-16
Start date
2022-05-10
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedentary Behavior

Interventions

Participants in the present study were randomized using the randomizer software with an evaluator blinding scheme. Isometric training group: 30 participants of both sexes performed unsupervised breaks
I03.350

Sponsors

Universidade Federal Rural de Pernambuco
Lead Sponsor
Universidade Federal Rural de Pernambuco
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Do not have a diagnosis of cardiovascular disease and diabetes, do not have high cardiovascular risk, do not participate in the physical exercise program for at least six months, occupational activity that requires more than six sitting times per day, and, do not being a smoker or being on medication.

Exclusion criteria

Exclusion criteria: Show adherence below 85% of the training sessions, adhere to another supervised physical exercise program, and, change the characteristics of occupational activities.

Design outcomes

Primary

MeasureTime frame
It is expected after a 12-week period to observe changes in flow-mediated dilation (FMD). The measurements will be verified by means of ultrasound. Images of the popliteal artery will be recorded by a two-dimensional ultrasound device with spectral Doppler and linear transducer. Diameter and basal blood flow will be recorded continuously over 90 seconds. After the basal recording, a cuff will be inflated, positioned five fingers below the popliteal fossa, which will have a pressure 50 mm Hg above the systolic blood pressure, measured before the exam. The occlusion will be maintained for 5 minutes and, after this period, released quickly. Doppler recordings will resume 30 seconds before the cuff is deflated and will be maintained for an additional 180 seconds.

Secondary

MeasureTime frame
It is expected after a period of 12 weeks to see reductions in ambulatory blood pressure values. The 24-hour ambulatory BP measurements will be verified using the ABPM (Dyna-MAPA, Cardios, Brazil). The equipment will be properly calibrated, with the cuff connected to the arm of the subjects' preference and following installation and use instructions in agreement with the manufacturer. The monitor will be programmed to take measurements at 15-minute intervals during the day and 30-minute intervals between 11:00 pm and 7:00 am. The individual will be instructed to record in a specific form any eventuality (daily or nightly) while using the MAPA.;It is expected after a period of 12 weeks to see reductions in clinical blood pressure values. Clinical blood pressure measurements will be verified using the omron HEM 742 equipment. For this measurement, the subjects will remain in dorsal decubitus for ten minutes, using an appropriate cuff for the circumference of the arm. Consecutive measurements will be performed one minute apart, on the right arm, until reaching a difference of less than 4 mmHg between two measurements.;It is expected after a period of 12 weeks to observe changes in the parameters of heart rate variability. The measurements will be verified by the technique of heart rate variability. For that, the subjects will remain lying down for 15 minutes, during which the RR intervals will be recorded, using a heart rate monitor valid for this function (Polar V800, Polar Electro, Finland). However, the first five minutes will be excluded and only those with at least five minutes of stationary signal, evaluated by an experienced researcher, will be considered a valid signal.

Countries

Brazil

Contacts

Public ContactBreno Farah

Universidade Federal Rural de Pernambuco

breno.farah@ufrpe.br+55 81 3320.5444

Outcome results

None listed

Source: REBEC (via WHO ICTRP)