Melasma
Conditions
Interventions
This is a prospective, randomized, comparative, parallel-group, double-blind clinical study. Fifty adult women with facial melasma without prior treatment for at least 30 days will be included. Partic
E05.318.308.980
Sponsors
Universidade Federal de São Paulo - UNIFESP
Universidade Federal de São Paulo - UNIFESP
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Adult women aged 18 to 65 will be included, with a clinical diagnosis of facial melasma without previous treatment, except for the use of sunscreen, for at least one month.
Exclusion criteria
Exclusion criteria: Participants with other facial dermatoses, pregnant or lactating women and immunosuppressed women will not be included. Women at risk for thromboembolism: using contraceptives or hormone replacement therapy, smokers, obese, sedentary or with a personal or family history of thrombosis will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expected primary outcome will be the relative reduction in mMASI on D30 and D90 for comparison between groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will be the relative reduction in MELASQol-BP, the difference in luminosity (*L) in colorimetry and histopathological findings, on D30 and D90 between the groups | — |
Countries
Brazil
Contacts
Public ContactDaniel Cassiano
Univesidade Estadual de São Paulo UNIFESP
Outcome results
None listed