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Evaluation of biomarkers and gene expression profile related to peripheral microvascular reserve in patients with severe infections

Evaluation of biomarkers and gene expression profile related to peripheral microvascular reserve in septic patients

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-10jksk74
Enrollment
Unknown
Registered
2022-01-28
Start date
2021-10-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

Blood samples will be collected for RNA extraction (total of 5 ml) from 168 consecutive patients admitted for sepsis to the Intensive Care Unit
D005796

Sponsors

Hospital de Clínicas - Universidade Federal do paraná
Lead Sponsor
Instituto Carlos Chagas - Fiocruz
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients; age above 18 years; diagnosed with sepsis; admitted to the Intensive Care Units

Exclusion criteria

Exclusion criteria: Pregnancy; refusal to participate in the study; exclusion of the sepsis diagnosis after data collection; diagnosis of acute SARS-COV2 (COVID-19) infection

Design outcomes

Primary

MeasureTime frame
In-hospital mortality rate, with 28-day survival curve, among septic patients with the MARS-1 genomic endotype, with the expectation that this endotype presents a mortality risk up to 2 times higher in this population—

Secondary

MeasureTime frame
In-hospital 28-day mortality rate of other genomic endotypes (MARS 2,3,4) among septic patients in Brazil;Correlation analysis between the four genomic endotypes and clinical, hemodynamic and protein markers variables—

Countries

Brazil

Contacts

Public ContactFernanda De Stefani
fe_destefani@yahoo.com+55(41)999821324

Outcome results

None listed

Source: REBEC (via WHO ICTRP)