Use of Scintigraphy in the evaluation of the response to Renal Denervation in patients with treatment-resistant hypertension

Use of Metaiodobenzylguanidine-123 Scintigraphy in the evaluation of the response to Renal Sympathetic Denervation in patients with treatment-resistant hypertension

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

REBEC

Registry ID

RBR-10h5gd44

Enrollment

Unknown

Registered

2023-05-05

Start date

2018-03-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

The present study was a prospective, randomized, single-center, double-blind clinical follow-up and placebo-controlled clinical trial, in which patients underwent noninvasive and invasive tests. The r

E02.808.750, E04.014.760

Eligibility

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: treatment resistant hypertension; age between 18 and 75 years old

Exclusion criteria

Exclusion criteria: Secondary hypertension; advanced chronic renal failure (creatinine clearance < 30 ml/min); abnormal renal vascular anatomy (diameter less than 3 mm; extent less than 20 mm; or stenosis greater than 30%); allergic reaction to the iodine contrast; pregnant women; unable to understand the study or sign the consent form; patients with decompensated heart failure; hemorrhagic diathesis; consumptive diseases; severe peripheral arterial obstructive disease; acute diseases such as coronary and cerebrovascular syndromes were excluded

Design outcomes

Primary

Measure	Time frame
Expected outcome 1: We expected to find reduced washout rates and increased heart/mediastinum (RCM), kidney/backside radiation (RD/BG and RE/BG) ratios after the renal denervation procedure. ;Outcome found 1: We observed that there was no statistical difference in the scintigraphic parameters at the different study times, before and after the randomized procedure, within and between the treatment and control groups, such as the heart/mediastinum ratio (MCR), kidney/backside radiation (RD/BG and RE/BG), and by the washout rates (RDW, REW, and MIOCW). As well as in the ratios between the two kidneys and liver (RD/FIG, RE/FIG), lung uptake (RD/PUL, RE/PUL), mediastinum (RD/MED, RE/MED), and the myocardium (RD/MIOC, RE/MIOC) on the 15-minute and 4-hour images.	—

Measure

Time frame

Expected outcome 1: We expected to find reduced washout rates and increased heart/mediastinum (RCM), kidney/backside radiation (RD/BG and RE/BG) ratios after the renal denervation procedure. ;Outcome found 1: We observed that there was no statistical difference in the scintigraphic parameters at the different study times, before and after the randomized procedure, within and between the treatment and control groups, such as the heart/mediastinum ratio (MCR), kidney/backside radiation (RD/BG and RE/BG), and by the washout rates (RDW, REW, and MIOCW). As well as in the ratios between the two kidneys and liver (RD/FIG, RE/FIG), lung uptake (RD/PUL, RE/PUL), mediastinum (RD/MED, RE/MED), and the myocardium (RD/MIOC, RE/MIOC) on the 15-minute and 4-hour images.

—

Secondary

Measure	Time frame
Secondary outcomes were not expected.	—

Countries

Brazil

Contacts

Public ContactCarlos Zeller

Instituto Dante Pazzanese de Cardiologia

cbzeller@gmail.com+55 11 50856000

Outcome results

None listed

Source: REBEC (via WHO ICTRP)