Smoking
Conditions
Interventions
The population of present prospective, randomized, controlled, double-blind, split-mouth clinical study were randomly assigned, using a computer-generated list generated a priori by a team member not
HCAN – healing chambers + dual thread design [thread within thread profile] and activated nanosurface - nano-sized HA according to the Promimic HAnano™ method 37 (UNITITE - S.I.N. IMPLANT SYSTEM) (n=3
D25.339.312
Sponsors
Universidade Paulista
Universidade Paulista
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Smokers who smoke more than 10 cigarettes/day; aged between 18 and 65 years; both genders; with the presence of at least 20 teeth in the oral cavity; bilateral and homologous unitary prosthetic space
Exclusion criteria
Exclusion criteria: Presence of systemic diseases that could interfere with bone regeneration, such as diabetes, arthritis, hypothyroidism, hyperparathyroidism, and osteoporosis; pregnancy or breastfeeding; use of medications that counter-indicated the performance of surgical procedures or that could alter bone regeneration around implants (e.g., anti-inflammatory and bisphosphonate drugs); absence of keratinized tissue at the implant insertion sites (may interfere with hygiene around the implants); need for bone or tissue grafts
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: Modifications in the implant geometry are expected to positively influence the bone markers studied, through immunoenzymatic analysis, increasing the concentration (pg/ml) of osteoblastogenic and angiogenic markers and reducing the concentration (pg/ml) of osteoclastogenic markers.;Found outcome 1: Using immunoenzymatic analysis, higher levels (pg/ml) of osteoblastogenic and angiogenic markers were observed in the presence of geometric modifications of the implants. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2: It is expected that periodic modifications will contribute to increasing the stability quotient of affected implants through resonance frequency analysis;Found outcome 2: It was found in the resonance frequency analysis, that the implant stability quotient presented higher values for HCAN implants at 60-day time-point (early phase) | — |
Countries
Brazil
Contacts
Public ContactMônica Correa
Universiade Paulista - UNIP
Outcome results
None listed