Middle Aged
Conditions
Interventions
This is a randomized, double-blind, placebo-controlled clinical trial with 16 physically active middle-aged men (mean ± SD: age 51.6 ± 4.4 years
BMI 25.8 ± 2.4 kg/m²). Participants were randomly assigned in equal numbers to one of two groups. Garlic group (n=8) received 700 mg/day of garlic extract orally for 14 consecutive days. Placebo group
Sponsors
University of non-governmental Qadir
University of non-governmental Qadir
Eligibility
Sex/Gender
Male
Age
44 Years to 62 Years
Inclusion criteria
Inclusion criteria: Physically active men playing soccer 2 to 3 sessions per week; non-smokers; free from supplement use, chronic illness, injury, or oral infections
Exclusion criteria
Exclusion criteria: Inability or unwillingness to perform the exercise protocol to exhaustion; failure to complete the full supplementation period; engagement in vigorous or unaccustomed physical activity within 48 hours prior to testing sessions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: Garlic supplementation will increase salivary antioxidant enzyme activity (superoxide dismutase, peroxidase, and catalase) and change saliva flow rate following exhaustive exercise in physically active middle-aged men.;Observed outcome 1: Garlic supplementation significantly increased superoxide dismutase, peroxidase, and catalase activity compared to placebo and decreased the superoxide dismutase/catalase ratio, indicating a favorable shift in enzymatic balance. No differences were observed in saliva flow rate between groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes expected. | — |
Countries
Islamic Republic of Iran
Contacts
Public ContactBehzad Taati
University of non-governmental Qadir
Outcome results
None listed