Urinary Bladder Underactive
Conditions
Interventions
Twenty individuals will be involved in the study randomly divided into 2 groups through a computer program.
GROUPS
Group A - GA (n = 10) Patient with detrusor hypocontractility and undergoing clean i
C12.777.829.893
Sponsors
Universidade Federal de Mato Grosso do Sul
Universidade Federal de Mato Grosso do Sul
Eligibility
Inclusion criteria
Inclusion criteria: The inclusion criteria will be male and female patients with a urodynamic study showing only detrusor hypocontractility, without the presence of an obstructive factor to the urinary flow. They must be in clean intermittent catheterization, not undergoing any surgical procedure in the lower urinary tract in the last 12 months.
Exclusion criteria
Exclusion criteria: Exclusion criteria: end-stage renal failure (with oligo-anuria), recurrent urinary tract infection, non-adherence to clinical monitoring protocols and clean intermittent auto-catheterization. Presence of any malignant neoplasm confirmed in treatment or recently treated or even any suspicion of cancer will be an important exclusion criterion due to contraindication to the use of stem cells in these patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome: improvement of bladder contractility Evaluation method: Urodynamic study. The urodynamic study was also carried out, which provided several data for comparative evaluation between the moment before and after the transplantation of stem cells. Maximum flow, medium flow, urine volume and post-voiding residue were obtained in the initial urofluxometry. In the stage of Differential Cystometry, information was obtained such as maximum cystometric capacity, complacency and the presence or absence of urinary losses or detrusor hyperactivity. In the flow-pressure study the data were maximum flow, detrusor pressure at maximum flow and detrusor contractility index calculated (Bladder contractility index: BCI = pdetqmax + 5 x Qmax). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome: Improved quality of life in relation to urinary incontinence symptoms The patients were submitted to the quality of life questionnaire in Urinary Incontinence (ICIQ-SF: International continence on incontinence questionaire - Short Form) before and after the intervention | — |
Countries
Brazil
Contacts
Public ContactHenrique Coelho
Outcome results
None listed