Strengthening the inspiratory muscles in obstructive sleep apnea

Inspiratory muscle training in individuals with obstructive sleep apnea

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-108s9fg4

Enrollment

Registered

2026-03-17

Start date

2026-03-15

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep Apnea Syndromes Respiratory Tract Diseases

Interventions

The study will adopt a quasi-experimental design involving inspiratory muscle training in a single group of individuals with obstructive sleep apnea. Based on previous studies, an initial sample of 20

and a second researcher will perform the statistical analyses. Initially, participants will be informed about the study objectives and procedures and, after reading and electronically signing the info

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years;men or women;diagnosis of obstructive sleep apnea;failure to adapt to continuous positive airway pressure therapy, low adherence to continuous positive airway pressure therapy (use for less than 4 hours on 70 percent of nights), or referral for conservative treatments (use of an intraoral appliance and orofacial myofunctional therapy);signing of the Informed Consent Form

Exclusion criteria

Exclusion criteria: Contraindications to inspiratory muscle training, such as: recent surgery (thoracic, abdominal, brain, ear, nose, and throat);pneumothorax;hemoptysis;pulmonary embolism;acute diarrhea or stress incontinence;dementia or any other condition in which the patient is unable to understand the test; patient discomfort; risk of infection;glaucoma or retinal detachment;abdominal hernia;recent acute myocardial infarction or unstable angina;severe arterial hypertension (systolic blood pressure greater than 200 millimeters of mercury and diastolic blood pressure greater than 120 millimeters of mercury);aortic aneurysm;neurological diseases;middle ear disorders;as well as inability to understand and/or perform the tests proposed for the study

Design outcomes

Primary

Measure	Time frame
To evaluate the apnea–hypopnea index using respiratory polygraphy and determine whether there was a reduction in the number of apnea and hypopnea events per hour.;To evaluate inspiratory muscle strength by measuring maximal inspiratory pressure using a digital manovacuometer and determine whether there was an increase in inspiratory muscle strength expressed in centimeters of water.;To evaluate inspiratory muscle endurance using the respiratory endurance test performed with the POWERbreathe KH2 device and determine whether there was an increase in the number of repetitions completed.	—

Measure

Time frame

To evaluate the apnea–hypopnea index using respiratory polygraphy and determine whether there was a reduction in the number of apnea and hypopnea events per hour.;To evaluate inspiratory muscle strength by measuring maximal inspiratory pressure using a digital manovacuometer and determine whether there was an increase in inspiratory muscle strength expressed in centimeters of water.;To evaluate inspiratory muscle endurance using the respiratory endurance test performed with the POWERbreathe KH2 device and determine whether there was an increase in the number of repetitions completed.

—

Secondary

Measure	Time frame
To evaluate functional capacity using the one-minute sit-to-stand test and determine whether there was an increase in the number of repetitions performed.;To evaluate variables obtained from overnight oximetry (mean peripheral oxygen saturation, minimum peripheral oxygen saturation, and time spent below 90%) through respiratory polygraphy and determine whether there was improvement in these parameters.;To evaluate ssess sleep quality using a specific questionnaire addressing signs and symptoms related to sleep-related breathing disorders and determine whether there was a reduction in the number of reported signs and symptoms.;To evaluate daytime sleepiness using the Epworth Sleepiness Scale and determine whether there was a reduction in the total score obtained on the scale.	—

Measure

Time frame

To evaluate functional capacity using the one-minute sit-to-stand test and determine whether there was an increase in the number of repetitions performed.;To evaluate variables obtained from overnight oximetry (mean peripheral oxygen saturation, minimum peripheral oxygen saturation, and time spent below 90%) through respiratory polygraphy and determine whether there was improvement in these parameters.;To evaluate ssess sleep quality using a specific questionnaire addressing signs and symptoms related to sleep-related breathing disorders and determine whether there was a reduction in the number of reported signs and symptoms.;To evaluate daytime sleepiness using the Epworth Sleepiness Scale and determine whether there was a reduction in the total score obtained on the scale.

—

Countries

Contacts

Public ContactMarcelo Velloso

Universidade Federal de Minas Gerais

marcello.vel@gmail.com+55-31-34094777

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Apr 4, 2026