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analysis of the inflammatory response of the dental pulp to direct pulp capping with polymeric nanoparticles of brasilian red propolis

Pulp response to direct capping with polymeric nanoparticles loaded with red propolis from Alagoas

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
REBEC
Registry ID
RBR-108988gj
Enrollment
Unknown
Registered
2021-10-01
Start date
2018-03-10
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dental pulp exposure

Interventions

32 individuals with indication for surgical removal of healthy third molars were considered eligible for participation in the study, totaling a sample of 60 teeth that were randomly allocated into 15
Group III (15 days) Group VIII (45 days) Group XIII (60 days) MTA+NPP(100) – NPP portion containing 100 micrograms of EBP. Group IV (15 days) Group IX (45 days) Group XIV (60 days) NPP(100) - NPP port
C07.793

Sponsors

Universidade Federal de Alagoas - UFAL
Lead Sponsor
Universidade Federal de Alagoas - UFAL
Collaborator

Eligibility

Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Individuals who signed the free and informed consent form; older than 18 years; under appropriate mental conditions to provide free and informed consent in writing; with extraction indicated for therapeutic reasons of healthy third molars; with good oral hygiene and without systemic impairment

Exclusion criteria

Exclusion criteria: Patients with poor oral hygiene; Bruxism; Periodontal disease; Caries; Restorations on any surface; pulp vitality; Impossibility of absolute isolation; systemic disease or health condition; Inability to cooperate with the requirements of the research protocol and follow-up procedures; Individuals who presented conditions associated with poor adherence to treatment, such as alcoholism, mental illness or drug dependence; Women who were pregnant or recently given birth (last 6 months); Team members (researchers and auxiliaries) directly linked to the study or their immediate relatives (spouse, parents, children, siblings); Patients with a history of allergic reactions to bee stings and / or products derived from honey from bees, whether or not containing propolis

Design outcomes

Primary

MeasureTime frame
neoformation of mineralized tissue (restorative dentin) after exposure of the pulp tissue evaluated by microscopic evaluation criteria of tissue morphology after 15, 45 and 60 days of intervention

Secondary

MeasureTime frame
inflammatory cellular response of the pulp and organization of the pulp tissue evaluated by microscopic evaluation criteria of the tissue morphology after 15, 45 and 60 days of intervention

Countries

Brazil

Contacts

Public ContactLilian Lira
lilian.silva@esenfar.ufal.br+55(82)988216283

Outcome results

None listed

Source: REBEC (via WHO ICTRP)