Alzheimers disease, Parkinson's disease, Healthy Volunteers
Conditions
Interventions
This is a randomized, double-blind, placebo-controlled clinical trial conducted in three phases.
Phase 1: Sixty healthy adults (18–60 years), of both sexes, will be recruited and randomly allocated in
n=30 sham) using a computer-generated randomization sequence. The intervention group will receive transcranial magnetic stimulation (TMS) applied to the left dorsolateral prefrontal cortex (DLPFC), ac
~15 minutes/session), and absence from more than two consecutive sessions will not be permitted. Cognitive assessments will be performed at two time points — baseline (pre-intervention) and post-inter
V03.175.250.500.500
D26.660
E02.621.820
Sponsors
Clínica Sinedor Ltda
Palm Serviços Médicos Ltda
Universidade Federal de Mato Grosso - Campus Sinop
Eligibility
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Adults aged between 18 and 60 years; both genders; individuals without neurological or psychiatric comorbidities; individuals with a clinical diagnosis of Parkinson's disease; individuals with a clinical diagnosis of Alzheimer's disease
Exclusion criteria
Exclusion criteria: Presence of cardiac pacemakers or other electronic implants; history of epilepsy or seizures; severe or unstable medical conditions that prevent the application of transcranial magnetic stimulation; refusal to sign the informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment through neuropsychological and neurological tests using validated tools. For patients with Alzheimer's disease and Parkinson's disease, specific and appropriate scales will be applied, taking into account the stage and severity of the clinical condition in both cognitive and neurological evaluations. | — |
Secondary
| Measure | Time frame |
|---|---|
| Monitoring of adverse effects related to the treatment, including but not limited to: headache, dizziness, local scalp discomfort, drowsiness, fatigue, mood changes, and tingling sensation.;Subjective evaluation of the intervention through a treatment satisfaction scale, assessing the participant’s perception of potential changes in daily life, particularly regarding cognition, memory, attention, concentration, and performance in routine activities. | — |
Countries
Brazil, United States
Contacts
Public ContactGuilherme de Paula
Universidade Federal de Mato Grosso - Campus Sinop
Outcome results
None listed