Alzheimer&apos
Conditions
Interventions
This is a randomized, double-blind, sham-controlled clinical trial in adults aged 18 to 80 years, conducted in three clinical cohorts: adults without neurological comorbidities, patients with Parkinso
Sponsors
Clínica Sinedor Ltda
Palm Serviços Médicos Ltda
Universidade Federal de Mato Grosso - Campus Sinop
Eligibility
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Adults aged 18 to 80 years, of either sex; individuals without neurological comorbidities or with a clinical diagnosis of Parkinson’s disease or Alzheimer’s disease; ability to undergo the planned cognitive assessments and transcranial magnetic stimulation procedures; agreement to participate by signing the informed consent form, directly or through a legal representative when applicable
Exclusion criteria
Exclusion criteria: History of epilepsy or unprovoked seizures; severe or unstable clinical conditions that contraindicate participation in the study; contraindications to transcranial magnetic stimulation identified on clinical screening or according to device safety recommendations; inability to complete the proposed assessments or stimulation procedures; refusal to sign the informed consent form, directly or through a legal representative when applicable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in cognitive performance and sleep quality from baseline to immediately after the 20th stimulation session, assessed through validated neuropsychological tests and the Pittsburgh Sleep Quality Index (PSQI), according to the participant’s clinical cohort. | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence, frequency, and severity of adverse events related to the intervention, evaluated throughout the stimulation sessions and follow-up period, in order to assess the safety and tolerability of transcranial magnetic stimulation.;Subjective perception of changes related to the intervention, including perceived cognitive performance, sleep quality, attention, concentration, well-being, and performance in daily activities, assessed through participant-reported measures. | — |
Countries
BR
Contacts
Public ContactGuilherme de Paula
Universidade Federal de Mato Grosso - Campus Sinop
Outcome results
None listed