FindTrial
Sign In

Influence of BsmI Polymorphism genetic variation on the effect of high doses of Vitamin D supplementation on Inflammation, Stress, Methylation and Bone Mineral Density in patients with Cystic Fibrosis

Influence of the BsmI Polymorphism (rs 1544410) of the VDR gene on the effect of Supplementation with Megadoses of Vitamina D 3, Process Inflammatory and Oxidative Estress, Metthylation of the VDR Gene and Bone Mineral Density in patients com Cystic Fibrosis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-104yt7rh
Enrollment
Unknown
Registered
2021-09-08
Start date
2018-08-10
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin D Deficiency

Interventions

A group of 27 patients previously diagnosed with vitamin D insufficiency, were supplemented with vitamin D 3 megadose, 4000 IU daily from Monday to Friday for children between 5 and 10 years old and 1
G07.203.300.456

Sponsors

Universidade Federal da Paraíba
Lead Sponsor
Instituto de Medicina Integral Professor Fernando Figueira - IMIP/PE
Collaborator

Eligibility

Age
5 Years to No maximum

Inclusion criteria

Inclusion criteria: Volunteers followed at the clinic with a diagnosis of Cystic Fibrosis; both genders; over 5 years of age; clinically stable; no use of vitamin D megadose

Exclusion criteria

Exclusion criteria: Patients with kidney or liver failure; patients on the waiting list for lung or kidney transplantation; who did not accept to participate in the research

Design outcomes

Primary

MeasureTime frame
Expected to find an increase in 25(OH)D levels after the intervention;Different responses to supplementation according to genotypes of the BsmI polymorphism of the VDR gene—

Secondary

MeasureTime frame
It is expected that after supplementation, there will be a reduction in inflammatory process and oxidative stress markers—

Countries

Brazil

Contacts

Public ContactDayanna Queiroz
dayannajoyse@hotmail.com(55) 83 996296511

Outcome results

None listed

Source: REBEC (via WHO ICTRP)