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Effectiveness and safety evaluate of Covid-19 vaccines by the National Immunization Program: a multicenter cohort study in brazilian healthcare workers

Effectiveness and safety of Covid-19 vaccines by the National Immunization Program: a multicenter cohort study in healthcare workers

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-1034tqgd
Enrollment
Unknown
Registered
2025-06-24
Start date
2021-09-27
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 Vaccines

Interventions

The study aims to evaluate the effectiveness and safety of COVID-19 vaccines made available to healthcare professionals (HCWs). This is a multicenter observational study of the dynamic cohort type, co
2) HCWs not vaccinated against COVID-19, with a total of 14 participants. HCWs of any age, technical or higher level, and with an active link with the participating institutions or other health units
2) seroneutralization rate against Sars-Cov-2 pseudovirus
and 3) quality of the cellular immune response in a subgroup of study participants.
V03.175.500

Sponsors

Empresa Brasileira de Serviços Hospitalares
Lead Sponsor
Ministério da Saúde
Collaborator
Instituto Nacional de Cardiologia
Collaborator
Hospital Universitário Pedro Ernesto – Universidade do Estado do Rio de Janeiro
Collaborator
Hospital Escola da Universidade Federal de Pelotas
Collaborator
Hospital Universitário de Brasília - Universidade de Brasília
Collaborator
Hospital das Clínicas - Universidade Federal de Minas Gerais
Collaborator
Hospital Universitário Cassiano Antonio Moraes - Universidade Federal do Espiríto Santo
Collaborator
Hospital Universitário Maria Aparecida Pedrossian - Universidade Federal do Mato Grosso do Sul
Collaborator
Hospital Universitário de Sergipe - Universidade Federal de Sergipe
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Healthcare workers; over the age of 18; both sexes; working in the public and/or private healthcare system in of Brazil

Exclusion criteria

Exclusion criteria: Individuals who had been vaccinated for COVID-19 in a clinical trial taking place in parallel at the research sites

Design outcomes

Primary

MeasureTime frame
Evaluate the efficacy and safety of the COVID-19 vaccines from the National Immunization Program (PNI) in healthcare professionals—

Secondary

MeasureTime frame
Evaluate the effectiveness of vaccines with moderate and severe disease as the outcome, as well as adverse events following immunization (AEFI) and the immune response of the population studied—

Countries

Brazil

Contacts

Public ContactDayde Da Silva

Universidade de Brasília

daydelane@gmail.com+55 (61) 992712604

Outcome results

None listed

Source: REBEC (via WHO ICTRP)