Drug Resistant Epilepsy
Conditions
Interventions
This is a randomized controlled two-arm double-blind clinical study with 60 participants, including 30 participants in each group. Participants will be randomly allocated between groups. Blinding will
Sponsors
Pós Graduação em Neuropsiquiatria e Ciências do Comportamento
Universidade Federal de Pernambuco
Eligibility
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Participants of both sexes; age between 18 and 60 years; clinical diagnosis of refractory epilepsy
Exclusion criteria
Exclusion criteria: Participants with associated brain disease; hearing impairment; participation in another research study; inability to attend evaluation and intervention sessions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effect of Non-Periodic Binaural Acoustic Stimulation on the brain electrical activity of patients with epilepsy. The outcome will be assessed through electroencephalography (EEG) performed before and after the intervention. Changes in epileptiform activity and electroencephalographic parameters obtained from the EEG will be analyzed by comparing pre- and post-intervention results. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate seizure frequency, quality of life, and cognition in participants after the intervention with Non-Periodic Binaural Acoustic Stimulation. The outcome will be assessed using the Seizure Diary, the Quality of Life in Epilepsy Inventory (QOLIE-31), and the Patient Global Impression of Change Scale (PGIS/PIGS). Reductions in seizure frequency, improvements in quality-of-life scores, and improvements in global perception of change will be analyzed by comparing post-intervention results with baseline assessments. | — |
Countries
BR
Contacts
Public ContactMarilia Lucena
Universidade Federal de Pernambuco
Outcome results
None listed