FindTrial
Sign In

The effect of Strength Exercise with Blood Flow Restriction using different Pressure Levels in the elderly

Physiological marker responses to Resistance Exercise with Blood Flow Restriction using different Occlusion Pressures in older adults

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-102fn4kd
Enrollment
Unknown
Registered
2025-07-21
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Strength

Interventions

E02.760.169.063.500.387.875
E02.760.169.063.500.387.125
This study is characterized as a randomized crossover clinical trial. In this experimental study design, participants receive multiple treatments in sequence, acting as their own controls. The subject
Low-intensity resistance exercise with blood flow restriction corresponding to 40% of occlusion pressure and a load of 30% of 1RM (LIRE30%+BFR40%, N = 8)
Resistance exercise with blood flow restriction corresponding to 5% of the occlusion pressure and a load of 70% of 1RM (RE70%+BFR5%, N = 8) and
Resistance exercise with blood flow restriction corresponding to 5% of the occlusion pressure and a load of 30% of 1RM (LIRE30%+BFR5%, N = 8). The study design is crossover, so all groups will undergo
G11.427.410.698.277
E02.760.169.063.500.387

Sponsors

Felipe Corbellini
Lead Sponsor
Universidade Comunitária da Região de Chapecó - Unochapecó
Collaborator

Eligibility

Age
60 Years to 70 Years

Inclusion criteria

Inclusion criteria: The study will include elderly individuals aged 60 to 70 years old; of both genders; and who do not have a routine of systematic physical exercise.

Exclusion criteria

Exclusion criteria: Individuals with severe arterial and/or venous insufficiency (assessed by VLab-4000); joint or mobility problems that prevent and/or limit the performance of the exercises predetermined by the protocol; and endocrine dysfunctions related to the biomarkers analyzed in the study will be excluded

Design outcomes

Primary

MeasureTime frame
Evaluate hormonal responses through the markers Growth Hormone - GH, Insulin-like Growth Factor 1 - IGF-1, Testosterone, and Cortisol, using the ELISA plate reader.;Evaluate immune responses through the markers Interleukin-2, Interleukin-4, Interleukin-6, Interleukin-10, Tumor Necrosis Factor Alpha - TNF-a, and Interferon-Gamma - IFN-?, using the BDTM Cytometric Bead Array (CBA) kit applied to serum samples. ;Evaluate oxidative stress responses through the markers Nitric Oxide - NO, Carbonylated Proteins, Reactive Oxygen Species, Superoxide Dismutase - SOD, Catalase - CAT, Thiobarbituric Acid Reactive Substances - TBARS, and Myeloperoxidase - MPO, using a water bath, ELISA plate reader, and fluorescence reader.;Evaluate the responses of the Purinergic System components through ATP level markers using a commercial kit and ELISA plate reader; P1 and P2 receptors using real-time polymerase chain reaction (RT-PCR) equipment; and Ectonucleotidases using RT-PCR and ELISA plate reader.—

Secondary

MeasureTime frame
Evaluate the subjective perception of effort and pain perception, using the CR-10 scales and Visual Analog Scale (VAS);Evaluate blood pressure using a mercury column sphygmomanometer and a stethoscope;Evaluate venous reflux and pulse wave using the VLab-4000 equipment (computerized plethysmography equipment)—

Countries

Brazil

Contacts

Public ContactFelipe Corbellini

Universidade Comunitária da Região de Chapecó - Unochapecó

corbellini@unochapeco.edu.br+55(54)99194-0864

Outcome results

None listed

Source: REBEC (via WHO ICTRP)