None listed
Conditions
Interventions
NEWBORNS WILL RECEIVE ORAL BOVINE LACTOFERRIN (200mg/kg/day DIVIDED INTO THREE DAILY DOSE) OR PLACEBO (MALTODEXTRIN 200mg/kg/day DIVIDED INTO THREE DAILY DOSE) FOR 8 WEEKS. BOTH BOVINE AS WELL AS HUMA
THE IDENTITY OF THE SEQUENCE IS 69% (PIERCE ET AL, 1991). 3-D STRUCTURES OF BOVINE AND HUMAN LACTOFERRIN ARE VERY SIMILAR. LACTOFERRIN CONCENTRATION IN HUMAN MILK IS ESTIMATED TO BE 5.3 ± 1.9 MG / ML
HAMOSH, 2001). IN CONTRAST, LACTOFERRIN CONCENTRATION IN BOVINE MILK IS LOW (1.5 mg/mL IN SERUM OF COLOSTRUM AND 20-200 µg/mL IN MILK) (STEIJNS & VAN HOOIJDONK, 2000). ALTHOUGH THERE ARE DIFFERENCES I
TOMITA, 2002).
AS PRODUCED MILK VOLUME INCREASES, DECREASES LACTOFERRIN CONCENTRATION. EXIST VARIABILITY IN EVERY MOTHER, HOWEVER THE TOTAL AMOUNT OF NATURAL HUMAN LACTOFERRIN IN MILK CONSUMED BY A
Sponsors
UNIVERSIDAD PERUANA CAYETANO HEREDIA,
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1.NEONATES WITH BIRTH WEIGHT BETWEEN 500G and 2000G AT BIRTH TIME. 2. NEONATES BORN IN OR REFERRED TO, THE INTENSIVE OR INTERMEDIATE CARE UNIT OF NEONATOLOGY OF PARTICIPATING HOSPITALS BEFORE MENTIONED, IN THE FIRST 72 HOURS OF LIFE.
Exclusion criteria
Exclusion criteria: 1. NEONATES WITH UNDERLYING GASTROINTESTINAL PROBLEMS THAT MAKES IMPOSSIBLE ORAL ROUTE. 2. NEONATES WITH UNDERLYING CONDITIONS DEEPLY AFFECTING GROWTH AND DEVELOPMENT (CHROMOSOMAL ABNORMALITIES, STRUCTURAL BRAIN ABNORMALITIES, SEVERE CONGENITAL ABNORMALITIES). 3. NEONATES WITH A FAMILIAR HISTORY OF ALLERGY TO COW´S MILK. 4. ANY NEONATE THAT IN AGREEMENT WITH THE RESEARCHER´S CRITERIA DON´T HAVE THE POSSIBILITY TO COMPLETE THE STUDY MONITORING VISITS (PATIENT THAT BEFORE TWO MONTHS OF AGE MUST RETURN TO PROVINCE). 5. NEONATES WHOSE PARENTS DO NOT WANT TO PARTICIPATE.
Countries
Peru
Contacts
Public ContactJaime Zegarra
UNIVERSIDAD PERUANA CAYETANO HEREDIA
Outcome results
None listed