None listed
Conditions
Interventions
Corticosteroids Type of group
1. Add 20cc. of water to inject to a 2 gr ampoule. and mix properly
2. Add the contents of the vial to the 100 cc bag. of NaCI 0.9%
3. Administer the infusion for 1 hour.
Group name:Placebo Type of group
1. Add 20cc. of water to inject into a placebo ampoule and mix properly
2. Add the contents of the vial to the 100 cc bag. of NaCI 0.9%
3. Administer the infusion for 1 hour.
Sponsors
LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE,
Eligibility
Inclusion criteria
Inclusion criteria: All patients 16 years of age and older are eligible, with cranial trauma in which, in the absence of sedation, they obtain a score of 14 or less in the first 8 hours of the trauma. Although it is allowed to admit patients up to a maximum of 8 hours post-trauma.
Exclusion criteria
Exclusion criteria: The routine exclusion of patients with gastrointestinal disorders or pregnancy is unnecessary, unless the responsible physician considers that there is a definitive contraindication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome name:• Death from any cause within the first two weeks of trauma • Death or dependence six months after the trauma. Measure:Effects of corticosteroids on mortality or disability secondary to major acute cranial trauma. Timepoints:week two | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome name:not contemplated Measure:not contemplated Timepoints:not contemplated | — |
Countries
Peru, United States
Outcome results
None listed