None listed
Conditions
Interventions
Conservative (CON) Strategy
In participants randomized to the CON strategy, initial management with OMT alone will be employed (described below). A fundamental principle of the CON strategy is to
Sponsors
National Heart, Lung, and Blood Institute,
Eligibility
Age
21 Years to 99 Years
Inclusion criteria
Inclusion criteria: At least moderate ischemia on a stress imaging test with nuclear myocardial perfusion (≥10% myocardium), echo or cardiac magnetic resonance wall motion (≥3/16 segments with stress-induced severe hypokinesis or akinesis), or cardiac magnetic resonance perfusion (≥12% myocardium). Participant is willing to comply with all aspects of the protocol, including adherence to medical therapy and follow-up visits. Participant is willing to give written informed consent. Age ≥ 21 years
Exclusion criteria
Exclusion criteria: LVEF 50% on prior coronary computed tomography angiography (CCTA) or prior cardiac catheterization (if available). Finding of “no obstructive CAD” (<50% stenosis in all major epicardial vessels) on prior CCTA or prior catheterization, performed within 12 months Prior known coronary anatomy unsuitable for either PCI or CABG Unacceptable level of angina despite maximal medical therapy Very dissatisfied with medical management of angina History of noncompliance with medical therapy Acute coronary syndrome within the previous 2 months PCI or CABG within the previous 12 months Stroke within the previous 6 months or intracranial hemorrhage at any time History of ventricular tachycardia requiring therapy for termination, or symptomatic sustained ventricular tachycardia NYHA class III-IV heart failure at entry or hospitalization for exacerbation of chronic heart failure within the previous 6 months Non-ischemic dilated or hypertrophic cardiomyopathy End stage renal disease on dialysis or estimated glomerular filtration rate (eGFR) <30mL/min. (Please, check the 5.3 Protocol section).
Countries
Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, China, France, Germany, Hungary, India, Israel, Italy, Japan, Korea North, Korea South, Lithuania, Macedonia, Mexico, New Zealand, Peru, Poland, Portugal, Russian Federation, Serbia, Singapore, Spain, Switzerland, Thailand, United Kindgdom, United States
Contacts
Public ContactWalter Enrique Mogrovejo
Instituto Neuro Cardiovascular de las Americas (INCA)
Outcome results
None listed