None listed
Conditions
Interventions
Metoprolol Type of group
Metoprolol will be administered in patients with moderate to high risk who go to non-cardiac surgery.
Group name:placebo Type of group
Metoprolol placebo will be administered in patients with moderate to high risk who go to non-cardiac surgery.
Sponsors
POPULATION HEALTH RESEARCH INSTITUTE DE LA UNIVERSIDAD MC MASTER DE CANADA,
Eligibility
Inclusion criteria
Inclusion criteria: 1. They are> 45 years old 2. They have an expectation of postoperative stay> at 24 hours for surgical reasons 3. Meet any of the following 6 criteria: A. history of coronary artery disease B. Vascular artery disease C. History of Stroke D. Hospitalization by ICC within 3 years prior to randomization. E. Patients going to vascular surgery
Exclusion criteria
Exclusion criteria: 1. Contraindication for metoprolol 2. There is a clinical need for beta-blocker use preoperatively or during the first 30 days postoperatively 3. Previous adverse reaction to a beta blocker 4. Coronary revascularization surgery in the previous 5 years and no evidence of cardiac ischemia since surgery 5. Patients who undergo low-risk surgical procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome name:The patients heart rate and systolic blood pressure. Measure:Impact of the perioperative administration of metoprolol on cardiovascular events in the first 30 days after surgery in patients with moderate and high risk of postoperative cardiac events. Timepoints:6 to 12 hours immediately after the postoperative period, first, second and thirtieth postoperative days | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome name:significant atrial fibrillation, rehospitalization due to cardiac causes, AML, cardiac arrest, cardiovascular death, and the need for revascularization procedures. Measure:Perioperative effect of metoprolol at risk in the first 30 days of significant atrial fibrillation, rehospitalization due to cardiac causes, AML, cardiac arrest, cardiovascular death, and the need for revascularization procedures. Timepoints:30 first days | — |
Countries
Peru
Outcome results
None listed