None listed
Conditions
Interventions
Year 1, minimum intervention model. Group of Humans Type of group
This group will be treated with massive treatments of Niclosamide 1 to 2 g PO according to weight (Children between 11 and 34 kg: 1 g, Children over 34 kg: 1.5 g, Adults: 2 g), every 4 months for a total of 2 doses The treatment of this group will begin 1 month after the treatment of the pigs of the same communities.
Group name:Year of Stagnation 2. Population of Talar and Sullana
Type of group
In human population: Three rounds of mass treatment of taeniasis with niclosamide 1 to 2 g PO QD according to weight will be applied (Children between 11 and 34 kg: 1 g, Children over 34 kg: 1.5 g, Adults: 2 g) , months 1, 5 and 9.
In swine population Five rounds of massive treatment with Oxfendazole at maximum dose PO, months 0, 2, 4, 6, and 8. Recombinant vaccine TS0L18 IM months 0 and 4. Vaccine against swine cholera months 0, 2 and 4 .
Sponsors
BILL & MELINDA GATES FOUNDATION,
Eligibility
Inclusion criteria
Inclusion criteria: - Resident of the rural areas of Tumbes, Talara and Sullana (who stays at least two nights in the community) - Resident over two years.
Exclusion criteria
Exclusion criteria: - Residents who refuse to participate in the study. - Women in gestation will not receive massive treatment of niclosamide. - Participants with a history of adverse effects to nidosamide will not participate in the mass treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome name:Application of 6 different models for the control of taeniasis in human and porcine population. After this the 2 most successful models of intervention are applied at large scale Measure:Development and evaluation of a new control strategy for the treatment of taeniasis and human and porcine neurocysticercosis Timepoints:48 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome name:Serological samples in blood, urine and faeces in humans and swine population: Western Blot technique to detect antibodies against teniosis. Concentration technique for the detection of eggs. Copro antigen technique. Necropsy of swine population. Measure:Demonstration of the interruption of the transmission of T. solium. Timepoints:The samples of blood, feces, urine both porcine and human were taken according to the different calendars of each of the 6 models during the 4 years of intervention. Samples could be taken before or after the administration of treatment. ; Outcome name:Determination of incidence and prevalence of epileptic seizure events in the study area and through periodic monitoring of the incidence and prevalence of porcine cysticercosis seropositivity in Western Blot tests to detect antibodies against teniosis, of concentration for the detection of eggs, co-antigen test and necropsy of porcine population. Measure:Impact of the intervention Timepoints:An evaluation will be made after the intervention during each year to estimate the prevalence and incidence of taeniasis and human or porcine cysticercosis. The samples of blood, feces, urine both porcine and human were taken according to the different calendars of each of the 6 models during the 4 years of intervention. They can be taken before or after the administration of treatment. ; Outcome name:Efficacy of the treatment: Seropositivity in the Western Blot, egg concentration, coproantigen and necropsy tests of the swine population. Economic impact: Socio-economic census that will include characteristics of geographical location, characteristics of housing, family members, raising pigs and other animals, characteristics and location of breeding sites, breeding conditions, type of feeding and water status . Measure: 776/5000 Efficacy of the treatment. Economic impact of the interventions. Timepoints:The samples of blood, feces | — |
Countries
Peru
Contacts
Public ContactMONICA VERA
UNIVERSIDAD PERUANA CAYETANO HEREDIA
Outcome results
None listed