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Comparative Efficacy of Preoperative Analgesics on The Success of Inferior Alveolar Nerve Block in Mandibular Molars with Acute Irreversible Pulpitis: A Randomized Controlled Clinical Trial

Comparative Efficacy of Preoperative Analgesics on The Success of Inferior Alveolar Nerve Block in Mandibular Molars with Acute Irreversible Pulpitis: A Randomized Controlled Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202608876687649
Enrollment
120
Registered
2026-08-12
Start date
2024-11-06
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Health Anaesthesia

Interventions

Trypsin Chymotrypsin Alphintern
Trypsin Chymotrypsin Ambezim G
Placebo

Sponsors

Misr International University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: * Patients aged 18–50 years. * Healthy individuals classified as ASA I or II. * Mandibular first or second molars diagnosed with acute irreversible pulpitis. * Moderate to severe spontaneous pain. * Positive response to electric pulp testing. * Prolonged response to cold testing. * Absence of periapical radiolucency. * Closed root apices. * Ability to understand the visual analogue scale.

Exclusion criteria

Exclusion criteria: * Allergy to NSAIDs or enzyme preparations. * Pregnancy or lactation. * Use of analgesics or anti-inflammatory medications within 12 hours. * History of gastrointestinal ulceration. * Hepatic or renal disease. * Teeth with swelling or sinus tract. * Teeth exhibiting periodontal pockets greater than 4 mm. * Previously initiated endodontic treatment. * Non-restorable teeth. * Patients unable to provide informed consent.

Design outcomes

Primary

MeasureTime frame
Success of inferior alveolar nerve block anesthesia, defined as the ability to complete access cavity preparation and initial pulp extirpation with no or mild pain without the need for supplemental anesthesia—

Secondary

MeasureTime frame
Electric pulp test EPT response; Pain intensity measured using the Visual Analog Scale (VAS)—

Countries

Egypt

Contacts

Public ContactMohamed Eltayeb

Associate professor faculty of oral and dental medicine Badr university at Cairo

eltayeb65@hotmail.com+201112737376

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026