Patient-Controlled Regional Analgesia versus Continuous Infusion through an Adductor Canal Catheter after Total Knee Arthroplasty

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202608780657625

Enrollment

120

Registered

2026-08-03

Start date

2026-08-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery Orthopaedics Anaesthesia

Interventions

PCRA

Continuous infusion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age =18 years. Scheduled for primary unilateral total knee arthroplasty. ASA physical status I–III. Planned spinal anesthesia with ultrasound-guided adductor canal catheter and IPACK block. Able to understand and operate the patient-controlled regional analgesia (PCRA) device. Able to provide written informed consent.

Exclusion criteria

Exclusion criteria: Patient refusal. Contraindication to spinal or regional anesthesia. Allergy or hypersensitivity to amide local anesthetics. Infection at the puncture site. Coagulopathy or therapeutic anticoagulation contraindicating regional anesthesia. Pre-existing severe lower limb neurological deficit or neuropathy. Chronic opioid use (daily opioid therapy for >3 months). Cognitive impairment or inability to use the PCRA device. Pregnancy or breastfeeding. Revision or bilateral total knee arthroplasty.

Design outcomes

Primary

Measure	Time frame
Cumulative intravenous morphine consumption (mg) during the first 48 postoperative hours.	—

Secondary

Measure	Time frame
Cumulative intravenous morphine consumption during the first 24 postoperative hours.;Time to first intravenous morphine administration.;Number of rescue morphine boluses administered;Total ropivacaine consumption through the adductor canal catheter.;Time to first standing.;Active knee flexion angle.;Quadriceps muscle strength assessed using the Medical Research Council (MRC) scale.;Incidence of postoperative complications (falls or near-falls, postoperative nausea and vomiting, respiratory events, delirium, and catheter-related complications).	—

Measure

Time frame

Cumulative intravenous morphine consumption during the first 24 postoperative hours.;Time to first intravenous morphine administration.;Number of rescue morphine boluses administered;Total ropivacaine consumption through the adductor canal catheter.;Time to first standing.;Active knee flexion angle.;Quadriceps muscle strength assessed using the Medical Research Council (MRC) scale.;Incidence of postoperative complications (falls or near-falls, postoperative nausea and vomiting, respiratory events, delirium, and catheter-related complications).

—

Countries

Tunisia

Contacts

Public ContactYassine Maktouf

Head of the department of anesthesiology and intensive care unit

yassine.maktouf@gmail.com0021629442333

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026