Which Dissociation Method Better Guides Surgical Dose Selection in Intermittent Exotropia? A Randomized Controlled Trial Comparing Monocular Occlusion and Pharmacological Penalization

Effect of Preoperative Dissociation Technique on Surgical Outcomes in Intermittent Exotropia: A Randomized Controlled Trial of Monocular Occlusion versus Atropine Penalization

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202607792697862

Enrollment

160

Registered

2026-07-07

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases Paediatrics

Interventions

Monocular occlusion

Atropine penalization

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Age 3–15 years. • Diagnosis of intermittent exotropia. • Basic or divergence-excess type. • Distance deviation =15 PD. • Scheduled for primary strabismus surgery. • Best corrected visual acuity appropriate for age. • Ability to complete follow-up for 12 months. • Written informed consent from parents or legal guardians.

Exclusion criteria

Exclusion criteria: • Previous strabismus surgery. • Paralytic or restrictive strabismus. • Sensory exotropia. • Neurological disorders affecting ocular motility. • Developmental delay interfering with examination. • Amblyopia (>2-line interocular difference). • Ocular pathology affecting visual function. • Inability to comply with follow-up.

Design outcomes

Primary

Measure	Time frame
•Successful postoperative alignment defined as ocular deviation within ±10 prism diopters (PD) of orthotropia at distance fixation.	—

Secondary

Measure	Time frame
•Recurrence rate. ;Exodrift magnitude. ;• Reoperation rate.	—

Countries

Egypt

Contacts

Public ContactEhab Moawad

Associate Professor

ehabmoawad@med.suez.edu.eg00201227513043

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026