Injury, Occupational Diseases, Poisoning
Conditions
Interventions
Haemothorax autotransfusion
Sponsors
Haemonetics Corporation are providing in kind device support by lending us the TEG6S analyser and providing cartridges for use
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Adults aged =18 years. • Haemothorax requiring drainage via ICC in the TEU. • A requirement for transfusion of blood products in the opinion of the treating clinician. Transfusion decisions in the TEU are made by senior medical staff based on clinical assessment of haemodynamic status, indicators of end-organ perfusion, and degree of ongoing blood loss; there is no formal protocolised trigger.
Exclusion criteria
Exclusion criteria: • Known pre-existing coagulopathy. • Known use of anticoagulant or antiplatelet medication within 7 days. • Suspicion of pleural blood contamination – defined as penetrating thoracoabdominal injury with suspected diaphragmatic injury and clinical or radiographic signs of concomitant hollow viscus injury (e.g. peritonism, haematemesis, or subdiaphragmatic free air). • Known malignant mesothelioma. • Enrolment in another interventional study likely to influence coagulation outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Within-subject changes in R time, as measured by TEG viscoelastic assay | — |
Secondary
| Measure | Time frame |
|---|---|
| • Within-subject changes in other TEG parameters (K time, a angle, maximum amplitude [MA], LY30) between T0 and T1. • Within-subject changes in PlateletMapping parameters (MA-ADP, MA-AA, MA-fibrin, percentage inhibition ADP, percentage inhibition AA) between T0 and T1. • Within-subject changes in venous blood gas parameters (haemoglobin, pH, ionised calcium, and lactate) between T0 and T1. ;In-hospital mortality, the documented incidence of sepsis, disseminated intravascular coagulation (DIC), acute respiratory distress syndrome (ARDS), and acute kidney injury (AKI). | — |
Countries
South Africa
Contacts
Public ContactNicholas Chapman
Trauma Registrar at Chris Hani Baragwanath Academic Hospital
Outcome results
None listed