Ultrasound-Guided intra-Articular injection of Autologous Bone Marrow Aspirate Concentrate versus Platelet-Rich Plasma or Hyaluronic Acid for Management of Chronic Knee Pain

Ultrasound-Guided intra-Articular injection of Autologous Bone Marrow Aspirate Concentrate versus Platelet Rich Plasma or Hyaluronic Acid Combined with Genicular Nerve Block for Management of Chronic Knee Osteoarthritis Pain: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202607608327898

Enrollment

187

Registered

2026-07-24

Start date

2023-09-15

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Knee osteoarthritis pain Orthopaedics Anaesthesia

Interventions

Intraarticular Hyaluronic Acid injection in knee joint combined with genicular nerve block

Intraarticular Bone Marrow Aspirate concentrate knee injection combined with genicular nerve block

Intraarticular Platelet Rich plasma injection in knee joint combined with genicular nerve block

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Chronic knee pain (>6 months) Failure of conservative management Willingness to comply with follow-up

Exclusion criteria

Exclusion criteria: Inflammatory arthritis Prior knee surgery within 12 months Systemic infection Coagulopathy Malignancy Pregnancy Any intra-articular injection within 3 months prior to enrollment

Design outcomes

Primary

Measure	Time frame
Pain assessed by Visual Analog Scale (VAS)	—

Secondary

Measure	Time frame
Functional improvement measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee Injury and Osteoarthritis Outcome Score (KOOS) at the same intervals. Radiographic assessment using calibrated X-rays Patient satisfaction and adverse events	—

Countries

Egypt

Contacts

Public ContactMohamed Nassar

Lecturer of Anaesthesia and Surgical intensive care Faculty of Medicine Alexandria University

m_nassar00@alexmed.edu.eg+201002413831

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026