Using brain and pain monitoring to improve sedation and comfort in critically ill patients: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202607572539325

Enrollment

300

Registered

2026-07-31

Start date

2026-08-15

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental and Behavioural Disorders Nervous System Diseases Critical care / ICU sedation and analgesia management” Anaesthesia

Interventions

CONOX

CONVENTIONAL

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age = 18 years ICU admission Requirement for invasive mechanical ventilation Expected need for continuous IV sedation = 24 hours Use of sedative and opioid agents

Exclusion criteria

Exclusion criteria: Severe primary neurological injury requiring dedicated neuro-monitoring protocols (optional) Status epilepticus requiring continuous EEG Severe pre-existing neurological impairment Expected death within 24 hours Contraindication to electrode placement Pregnancy

Design outcomes

Primary

Measure	Time frame
Proportion of time within target sedation range (RASS / BPS target and corresponding qCON / qNOX equivalence) during the first 72 hours	—

Secondary

Measure	Time frame
Total dose of sedatives Total opioid consumption Duration of mechanical ventilation Ventilator-free days at day 28 Incidence of ICU delirium (CAM-ICU) ICU length of stay	—

Countries

Tunisia

Contacts

Public ContactMariem Ben Abdallah

Medical Doctor

mariembenabdallah@gmail.com0021656778931

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026