Ginger, Gum Chewing, and Vitamin B Complex for Emesis Gravidarum .

Comparing the Efficacy of Ginger, Gum Chewing, and Vitamin B Complex as Alternative Modalities for Emesis Gravidarum .

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

PACTR

Registry ID

PACTR202607518080830

Enrollment

270

Registered

2026-07-07

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emesis Gravidarum

Interventions

Ginger

Vitamin B Complex

Chewing gum

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1.Pregnant women with nausea and/or vomiting of pregnancy (NVP) in the first trimester. 2.Singleton intrauterine pregnancy confirmed by ultrasound. 3.Emesis gravidarum with a Pregnancy-Unique Quantification of Emesis (PUQE-24) score between 4 and 12, including [Mild (4–6) and Moderate (7–12)].

Exclusion criteria

Exclusion criteria: 1.Hyperemesis gravidarum requiring hospitalization or intravenous fluids (or Severe NVP (PUQE score = 13) 2.Multiple pregnancies 3.Vesicular mole pregnancy 4.Electrolytes imbalance (Abnormal levels of Na & K) 5.Evidence of ketonuria or acetone (= +1) in urine suggestive of hyperemesis gravidarum or metabolic ketosis. 6.Known allergies or hypersensitivity to ginger, chewing gum ingredients, or vitamin B Complex. 7.Use of antiemetic drugs within the previous 24–48 hours. 8.Pre-existing gastrointestinal diseases (e.g., peptic ulcer, inflammatory bowel disease, previous gastric surgery). 9. Chronic systemic diseases (e.g., liver disease, kidney disease, uncontrolled diabetes, thyroid disorders, severe anemia). 10. Use of hormonal therapy, corticosteroids, or psychiatric medications. 11. Smoking, alcohol consumption, or substance abuse. 12. History of dental issues (e.g., damage, dentures, loose or crowned teeth) 13. Temporomandibular joint (TMJ) disorders or surgeries

Design outcomes

Primary

Measure	Time frame
1.To evaluate and quantify the efficacy of ginger tablets, gum chewing, and vitamin B complex in reducing the severity of nausea and vomiting of pregnancy (NVP) using a standardized assessment tool (e.g., the Pregnancy-Unique Quantified Emesis/Nausea [PUQE] score). 2.To analyze the therapeutic superiority among the three modalities to determine which intervention provides the most significant clinical improvement in maternal symptoms.	—

Measure

Time frame

1.To evaluate and quantify the efficacy of ginger tablets, gum chewing, and vitamin B complex in reducing the severity of nausea and vomiting of pregnancy (NVP) using a standardized assessment tool (e.g., the Pregnancy-Unique Quantified Emesis/Nausea [PUQE] score). 2.To analyze the therapeutic superiority among the three modalities to determine which intervention provides the most significant clinical improvement in maternal symptoms.

—

Secondary

Measure	Time frame
1. To assess maternal satisfaction among the three intervention groups after using treatment. 2. To identify the recurrence of symptoms after discontinuation of treatment.	—

Countries

Egypt

Contacts

Public ContactMohammed Eltawyl

egymud@yahoo.com00201220770588

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 10, 2026