Digestive System Surgery Anaesthesia
Conditions
Interventions
Lidocaine
Ketamine
Placebo
Sponsors
Anaesthesia and intensive care Department at Farhat HACHED University Teaching Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Elective laparoscopic cholecystectomy for uncomplicated gallstone disease - Age =18 years - An American Society of Anesthesiologists (ASA) physical status of I–III - Patient provided written informed consent
Exclusion criteria
Exclusion criteria: - History of chronic pain - Analgesic use within 24 h before surgery - Psychiatric disorders or antidepressant therapy - Inability to understand or use the visual analogue scale (VAS) - Body mass index >35 kg m-2 - Pregnancy or breastfeeding - Anticipated difficult airway requiring rapid-sequence induction - Acute cholecystitis - Contraindications to any study medication - Conversion to laparotomy was required - Postoperative abdominal drainage inserted - Major perioperative anaesthetic or surgical complications occurred during the first 24 postoperative hours - Postoperative admission to an intensive care unit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain intensity during the first 24 postoperative hours. Pain intensity was assessed using a 10-cm VAS at admission to the post-anaesthesia care unit (PACU) (E0) and at 6 h (E1), 12 h (E2), 18 h (E3), and 24 h (E4) after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Morphine consumption in the PACU, time to first rescue analgesic request, the proportion of patients requiring rescue analgesia, total intraoperative sufentanil consumption, sleep quality during the first postoperative night, and treatment-related adverse events. | — |
Countries
Tunisia
Contacts
Public ContactMayssa MSALLEM
fellow ship in medecine at Anaesthesia and intensive care Department of Farhat HACHED University Teaching Hospital Universite du centre
Outcome results
None listed