Dexamethasone vs. Dexmedetomidine in Nerve Blocks for Femoral-Popliteal Bypass Pain Management

Motor-Sparing Regional Anesthesia for Femoral-Popliteal Bypass Surgery: A Randomized Controlled Trial Comparing Adductor Canal Block combined with Infiltration between the Popliteal Artery and Capsule of the Knee Using Dexamethasone versus Dexmedetomidine as Perineural Adjuvants

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202607476059769

Enrollment

Registered

2026-07-22

Start date

2026-07-09

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Dexmedetomidine

Dexamethasone

No Adjuvant

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age: Adults aged 40 to 85 years Surgery: Scheduled for elective unilateral femoral-popliteal bypass surgery (either above-knee or below-knee) ASA Status: American Society of Anesthesiologists (ASA) physical status class II or III Consent: Able to provide written informed consent

Exclusion criteria

Exclusion criteria: Contraindications to spinal anesthesia (including coagulopathy, infection at the puncture site, or increased intracranial pressure) Contraindications to peripheral nerve blocks (including infection at the injection site) Known allergy to local anesthetics (bupivacaine), dexamethasone, or dexmedetomidine Chronic opioid use defined as more than 30 mg of oral nalbuphine equivalents daily for more than 3 months Pre-existing quadriceps weakness or peripheral neuropathy Severe hepatic impairment or severe renal impairment Pregnancy or breastfeeding Body mass index (BMI) greater than 40 kg/m²

Design outcomes

Primary

Measure	Time frame
Total postoperative opioid consumption	—

Secondary

Measure	Time frame
Time to first rescue analgesia	—

Countries

Egypt

Contacts

Public ContactAmira barakat

lecturer of anesthesia and surgical icu faculty of medicine mansoura university

amiy10102012@gmail.com+201021632382

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026