Surgery Fertility-female Uterine Fibroids (Leiomyomata), Postoperative Anaemia, Intraoperative Haemorrhage.
Conditions
Interventions
Intravenous Tranexamic Acid
Normal Saline
Sponsors
Wasiu Onasanya
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Symptomatic women of reproductive age scheduled for open abdominal myomectomy Confirmed diagnosis of uterine fibroids via ultrasonography Provision of written informed consent prior to enrollment
Exclusion criteria
Exclusion criteria: Postmenopausal status Current or recent use of gonadotropin-releasing hormone (GnRH) analogues History of previous myomectomy Underlying thromboembolic disease, ischemic heart disease, hepatic insufficiency, chronic kidney disease, or active malignancy Documented hypersensitivity to tranexamic acid (TXA) Maternal body mass index (BMI) > 30 kg/m² Use of factor IX complex concentrates, anti-inhibitor coagulant concentrates, or all-trans retinoic acid within 2 weeks prior to surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative estimated blood loss (EBL) | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative packed cell volume / haematocrit (HCT) and haemoglobin (Hb) concentrations;Allogeneic blood transfusion requirements and the total number of blood units transfused;Total operative duration and postoperative length of hospital stay | — |
Countries
Nigeria
Contacts
Public ContactAdeniyi Akiseku
Corresponding Author Olabisi Onabanjo University Teaching Hospital
Outcome results
None listed