Orthopaedics
Conditions
Interventions
placebo
vitamin C
Sponsors
Mona Raafat Elghamry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: patients aged 40–75 years both sex American Society of Anesthesiologists (ASA I-III) scheduled for primary unilateral total knee replacement surgeries
Exclusion criteria
Exclusion criteria: Patients having contraindication to the studied drug revision or previous surgery in the other knee chronic opioid use severe hepatic, renal or cardiac dysfunctions Psychiatric or cognitive disorders Neurological disorders affecting pain perception diabetes mellitus obesity any prolonged or complicated surgeries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute pain will be assessed by VAS score which will be recorded (at rest and on knee flexion) | — |
Secondary
| Measure | Time frame |
|---|---|
| Chronic pain will be assessed at the anesthesia clinic or by a phone call by VAS score at rest and during physiotherapy.;Total dose of rescue analgesia;Any complaints such as headache, nausea, vomiting, abdominal cramps, diarrhea, blurring of vision, sedation or dizziness will be recorded as side effects. ;Functional Outcome will be assessed by Oxford Knee Score (OKS) ;Neuropathic Pain Assessment will be done by DN4 questionnaire ;Quality of Life will be assessed by the Short-Form health survey (SF-36) questionnaire . | — |
Countries
Egypt
Contacts
Public ContactSameh Fathy
Assistant Professor Faculty of Medicine Tanta university
Outcome results
None listed