Soil Transmitted Helminths
Conditions
Interventions
Sponsors
Team Europe Initiative
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: School age children 5-15 years old, eligible to receive routine MDA according to national guidelines, and enrolled in selected schools in Burera District. Positive for T. Trichiura infection, with or without co-infection with other soil-transmitted helminths (Ascaris lumbricoides or hookworm) and/or schistosomiasis, as confirmed by baseline stool examination. Able to provide assent, with written informed consent obtained from a parent or legal guardian, and assent from the child. Willing to comply with study procedures, sample collection (stool, blood), and follow-up visits. Not currently participating in another clinical trial.
Exclusion criteria
Exclusion criteria: Presence of major illnesses, such as severe anemia and fever upon initial clinical assessment. History of acute or severe chronic disease. Recent use of anthelmintic drug or praziquantel (within past 4 weeks). Known allergy or hypersensitivity to any of the study drugs. Pregnancy and breastfeeding. Children under 5 years, or weighing less than 15 kg, or shorter than 90 cm. Individuals who do not reside in the study area
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this trial will be the parasitological cure rate (CR) for Trichuris trichiura, assessed as a binary variable (cured vs. not cured). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome will be safety, it will be assessed throughout the study period. All adverse events (AEs) will be monitored and documented with respect to incidence, type, severity, onset, and duration. AEs will be actively captured on Days 1, 2, and 7, as well as participant-initiated reporting between Days 3 and 6 | — |
Countries
Rwanda
Contacts
Public ContactParfait Ndizeye
PhD student in the University of Rwanda
Outcome results
None listed