Mental and Behavioural Disorders Nervous System Diseases Orthopaedics
Conditions
Interventions
Sponsors
University of Sfax
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age between 65 and 75 years (inclusive) 2. Body mass index (BMI) between 23.0 and 27.0 kg/m² 3. Sedentary lifestyle defined as less than 1 structured exercise session per week and less than 5,000 steps per day (measured by pedometer over 7 days) 4. Diagnosis of amnestic mild cognitive impairment (MCI) according to Petersen criteria, with Montreal Cognitive Assessment (MoCA) score between 22 and 26 (inclusive) and subjective cognitive complaint 5. Executive dysfunction, defined as Stroop color-word interference score greater than 35 seconds 6. Moderate psychological distress indicated by WHO-5 Well-Being Index score less than or equal to 15 or Perceived Stress Scale (PSS-10) score greater than or equal to 14 7. Stable medication use for at least three months prior to enrollment, excluding psychoactive drugs 8. Ability to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Dementia (MoCA score less than 22) 2. Major depressive disorder (Geriatric Depression Scale-15 greater than 10) or any other severe psychiatric condition 3. Current or past neurological disorder (e.g., Parkinson's disease, stroke, epilepsy, traumatic brain injury) 4. Unstable cardiovascular disease or severe osteoarthritis precluding moderate-intensity exercise 5. Use of benzodiazepines, antipsychotics, or anticholinergic antidepressants 6. Participation in another structured exercise or cognitive training program during the previous six months 7. Any other condition that would interfere with study participation or outcome assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Executive function measured using the Stroop Color-Word Interference Test (interference score in seconds);Psychological well-being measured using the WHO-5 Well-Being Index (total score 0–25);Perceived stress measured using the Perceived Stress Scale PSS-10 (total score 0–40) | — |
Secondary
| Measure | Time frame |
|---|---|
| Global cognitive status measured using the Montreal Cognitive Assessment (MoCA, total score 0–30);Working memory measured using a visual 2-back task (accuracy percentage);Cognitive flexibility measured using the Trail Making Test (TMT B-A difference score in seconds) | — |
Countries
Tunisia
Contacts
Public ContactKais El Abed
High Institute of Sport and Physical Education of Sfax
Outcome results
None listed