Digestive System
Conditions
Interventions
Vonoprazan based triple therapy
Rabeprazole based conventional triple therapy
Sponsors
Tropical Medicine Department Faculty of Medicine Alexandria University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Confirmed H. pylori infection by stool antigen testing and/or urea breath test. - Dyspeptic symptoms with clinical evidence of gastritis or peptic ulcer disease. - Treatment-naïve for H. pylori eradication therapy. - Able and willing to provide informed consent.
Exclusion criteria
Exclusion criteria: - Previous H. pylori eradication therapy. - Antibiotic use within the preceding 6 weeks. - Pregnancy or lactation. - Known allergy to any study medication. - Gastrointestinal malignancy or active gastrointestinal bleeding. - Severe systemic disease or significant comorbidities interfering with study participation or outcome assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Successful H. pylori eradication, defined as a negative monoclonal stool antigen test after completion of eradication therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events and overall side effects | — |
Countries
Egypt
Contacts
Public ContactElsayedamr Basma
Patient Information Manager
Outcome results
None listed