Respiratory
Conditions
Interventions
Open suction with PCV
Open suction with VCV
Closed suction with PCV
Closed suction with VCV
Sponsors
Faculty of Applied Health Science Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Adults =18 years having an indwelling arterial line. • Intubated and mechanically ventilated =12 hours • Clinically stable: o FiO2 = 0.6 o PEEP = 10 cmH2O o No spontaneous effort • Expected ongoing ventilation for =4 hours
Exclusion criteria
Exclusion criteria: • PaO2/FiO2 < 100 mmHg • Hemodynamic instability requiring escalating vasopressors • Pneumothorax, bronchopleural fistula, or air-leak syndrome • Raised intracranial pressure, severe arrhythmias, or inability to tolerate suctioning • Pregnancy • If the arterial line is removed for clinical reasons before completing all study periods, the participant will be withdrawn from further interventions, but data collected up to that point will remain included in the intention-to-treat analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2/FiO2 Ratio AUC 0–60 min, determined from ABG sampling | — |
Secondary
| Measure | Time frame |
|---|---|
| • PaO2, PaCO2, SpO2 at all timepoints;SpO2 nadir and time SpO2 <90% / <85%: derived from continuous SpO2 monitoring from pre-oxygenation through 60 minutes.;Hemodynamics (MAP, HR);Safety events (hypoxemia, hypotension, arrhythmia, rescue maneuver) | — |
Countries
Egypt
Contacts
Public ContactAhmed alwazna
respiratory therapist. master degree student
Outcome results
None listed