Nervous System Diseases
Conditions
Interventions
A placebo 20mls of water for injection
Multispecies probiotic tablets
Sponsors
University of Ilorin Teaching Hospital
University of Ilorin Teaching Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All patients aged 18 years and above with severe traumatic brain injury who were admitted within 24 hours of the traumatic event, whose care givers consented to the study.
Exclusion criteria
Exclusion criteria: 1. Patients less than 18years of age. 2. Patients with features suggestive of basal skull fracture (anterior basal fracture) were excluded in order to prevent inadvertent passage of the nasogastric tube into the cranial cavity. 3. Patients with history suggestive of immunocompromise i.e. poorly controlled diabetes mellitus, HIV, prolonged steroid use, chronic kidney disease or liver cirrhosis. 4. Pregnant patients. 5. Patients who died within 24 hours of admission 6. Polytraumatized patients i.e patients with history suggestive of concomitant spinal cord injury, blunt or penetrating abdominal injury, chest trauma or skeletal injuries. 7. Patients with a previous history of use of probiotics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure in this study was the Glasgow Outcome Score Extended (GOS-E) in both the intervention and control groups | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The mean number of days taken to tolerate enteral feeding fully in each group. 2. The mean length of ICU stay of patients in each group. 3. The mean length of hospital stay of patients in each group. 4. The 30-day mortality in each group. | — |
Countries
Nigeria
Contacts
Public ContactOlukorede Adekunle
Consultant Neurosurgeon University of Ilorin Teaching Hospital
Outcome results
None listed