The effect of pulse pressure variation compared with superior vena cava collapsibility index and central venous pressure on intraoperative fluid management during kidney transplant surgery

The effect of pulse pressure variation compared with superior vena cava collapsibility index and central venous pressure on intraoperative fluid management during kidney transplant surgery: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202605884118906

Enrollment

Registered

2026-05-22

Start date

2024-09-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery Kidney Disease Anaesthesia

Interventions

Pulse pressure variation guided fluid therapy

Superior vena cava collapsibility index guided fluid therapy

Central venous pressure guided fluid therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age 18–65 years Both sexes ASA class III–IV Scheduled for kidney transplant surgery

Exclusion criteria

Exclusion criteria: Patient refusal Coronary artery disease Congestive heart failure Arrhythmias Severe valvular heart disease Contraindications to TEE (e.g., esophageal disease, varices, stricture, diverticulum)

Design outcomes

Primary

Measure	Time frame
Total volume of intraoperative fluids administered (mL)	—

Secondary

Measure	Time frame
Hemodynamic parameters Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, oxygen saturation;Hemodynamic monitoring indices Pulse Pressure Variation, Superior Vena Cava Collapsibility Index, Central Venous Pressure values;Laboratory parameters Serum lactate, Serum creatinine, Urea, Creatinine clearance;Graft function outcomes Immediate graft dysfunction (lack or decrease of urine output accompanied by absence of the expected decrease in serum creatinine) and Delayed graft dysfunction (need for dialysis);Clinical recovery outcomes ICU stay duration and Total hospital stay	—

Measure

Time frame

Hemodynamic parameters Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, oxygen saturation;Hemodynamic monitoring indices Pulse Pressure Variation, Superior Vena Cava Collapsibility Index, Central Venous Pressure values;Laboratory parameters Serum lactate, Serum creatinine, Urea, Creatinine clearance;Graft function outcomes Immediate graft dysfunction (lack or decrease of urine output accompanied by absence of the expected decrease in serum creatinine) and Delayed graft dysfunction (need for dialysis);Clinical recovery outcomes ICU stay duration and Total hospital stay

—

Countries

Egypt

Contacts

Public ContactIman Sarhan

Internal Medicine and Nephrology

Emansarhaan@yahoo.com+201227014846

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026