opioid free analgesia versus epidural analgesia in major abdominal surgeries

Effect of intravenous dexmedetomidine and lidocaine combination versus thoracic epidural analgesia on postoperative pain in major abdominal surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

PACTR

Registry ID

PACTR202605784091916

Enrollment

140

Registered

2026-05-06

Start date

2022-11-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Digestive System Anaesthesia

Interventions

combined infusion of intravenous dexmedetomidine and lidocaine

thoracic epidural analgesia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? American Society of Anesthesiologists (ASA) physical status I, II, or III. ? Age: 30-65 years old. ? Either sex. ? Patients will be scheduled for elective major abdominal surgery either open or laproscopy

Exclusion criteria

Exclusion criteria: ? Patients refuse epidural analgesia. ? morbid Obesity (body mass index >35). ? History of drug and alcohol abuse. ? Cerebrovascular and central nervous system diseases. ? Preexisting bleeding or coagulation disorders. ? Concomitant antiplatelet therapy. ? Known allergic diathesis to drugs and pregnancy. ? Severe respiratory, renal or hepatic disease. any contraindication to epidural catheterization like infection

Design outcomes

Primary

Measure	Time frame
?24 hours postoperative cumulative morphine consumption.	—

Secondary

Measure	Time frame
? Postoperative pain on visual analogue pain scale (VAS) at 1, 2, 4, 8, 12 and 24 after surgery. ? first analgesic request. ? Time to first bowel sounds and flatus. ? Postoperative sedation status and sleep quality. ? Mobilization and discharge time. ? Drug side effects (respiratory depression (fall in SpO2 of 30% of the baseline value) and bradycardia (HR < 60 beats / min), nausea and vomiting.	—

Countries

Egypt

Contacts

Public ContactOlfat moustafa

professor of faculty of medicine Mansoura university

olfatmi@hotmail.com+201223163041

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026