Respiratory
Conditions
Interventions
Improvised bubble CPAP
Sponsors
Armauer Hansen Research Institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All children aged 1-59 months with WHO classified severe pneumonia, admitted to study hospitals, will be assessed for inclusion. In addition, they will need to have at least one of these criteria: (i) Children with SpO2 =70/min and head nodding synchronous with respiration or nasal flaring or tracheal tugging). (iv) Parent or Legal guardian or caregiver is present and able to provide consent
Exclusion criteria
Exclusion criteria: 1. Known congenital heart disease 2. LRTI with wheeze responsive to bronchodilators and SpO2 = 90% 3. Stridor 4. Tracheostomy 5. Pneumothorax 6. Cerebral malaria on admission 7. Requirement for mechanical ventilation for any specific reason as decided by the clinician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment failure is defined if any of the following criteria is met: ? Presence of severe hypoxaemia (SpO2 < 90%) after one hour of receiving oxygen (either low-flow or bCPAP) ? Presence or worsening of respiratory distress signs after 48 hours of oxygen therapy ? Death during hospitalization ? Development of an indication for mechanical ventilation, as determined by the clinician ? Referral to a higher-level facility, as determined by the clinician | — |
Secondary
| Measure | Time frame |
|---|---|
| Inpatient Mortality;Length of Hospital Stay;Escalation of care, which includes clinician indication for mechanical ventilation, or referral for higher care at any point during their admission | — |
Countries
Ethiopia, Malawi, Nigeria
Contacts
Public ContactCynthia Baard
Project Manager
Outcome results
None listed