Nervous System Diseases ICU Anaesthesia
Conditions
Interventions
DSA guided management
Sponsors
Military University Hospital of Sfax
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Age = 18 years Admission to ICU At high risk of epileptic activity, defined by at least one of the following: Unexplained altered consciousness Recent clinical seizure Post–status epilepticus Intracerebral hemorrhage or subarachnoid hemorrhage Traumatic brain injury Acute ischemic stroke with cortical involvement Post–cardiac arrest coma Encephalitis or acute encephalopathy Neurosurgical patient with impaired consciousness Sepsis-associated encephalopathy with neurological fluctuation
Exclusion criteria
Exclusion criteria: Expected death or withdrawal of care within 24 hours Immediate access to continuous expert EEG monitoring already available Stable chronic epilepsy without acute deterioration Inability to apply EEG monitoring Known pregnancy Refusal of consent by patient or legal representative
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electrographic seizure burden within 72 hours after ICU admission, adjudicated by blinded expert EEG review. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to detection of epileptic activity Time to treatment initiation Incidence of non-convulsive seizures Incidence of non-convulsive status epilepticus Number of antiseizure treatment modifications Use of continuous EEG ICU length of stay Hospital length of stay ICU, 28-day, and 90-day mortality Neurological outcome at day 90 (mRS, CPC) Sedative and antiseizure drug exposure Adverse events (hypotension, oversedation, intubation) | — |
Countries
Tunisia
Contacts
Public ContactMariem Ben Abdallah
Medical doctor
Outcome results
None listed