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Bilateral Total vs. Bilateral Subcapsular Orchiectomy: A Study of Hormone Control Systems

Comparative Dynamics of Testosterone, Luteinizing Hormone and Follicle-Stimulating Hormone Following Bilateral Total Versus Subcapsular Orchidectomy For Advanced Prostate Cancer: A Prospective Randomized Study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
PACTR
Registry ID
PACTR202605689765402
Enrollment
60
Registered
2026-05-18
Start date
2026-03-16
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Surgery Urological and Genital Diseases

Interventions

Sponsors

MONDAY ELIBOH
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: • Adult male patients (=50 years to 89 years) with histologically confirmed prostate cancer that consent for orchidectomy and the study. • Only patients with prostate cancer classified as locally advanced or metastatic based on predefined clinical, biochemical, imaging, and histopathological criteria will be included.

Exclusion criteria

Exclusion criteria: • Patients with prior hormonal therapy (medical castration, anti androgens, or previous orchidectomy). • Patients on steroid medication for other conditions • Patients with contraindications to surgery, including those with severe cardiopulmonary disease, uncontrolled hypertension or diabetes mellitus, bleeding diatheses or uncorrected coagulopathies, active systemic infection. • Patients with concurrent testicular pathology.

Design outcomes

Primary

MeasureTime frame
To compare the hormonal profiles (testosterone, LH, and FSH) in patients undergoing BTO versus BSO for advanced prostate cancer

Secondary

MeasureTime frame
To evaluate the feedback correlation between testosterone, LH, and FSH within each surgical group.

Countries

Nigeria

Contacts

Public ContactSamson Ogunleye

Scientific Officer

ogunleyesamson@gmail.com+2347032069745

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026