Respiratory
Conditions
Interventions
CS followed by OS
OS followed by CS
Sponsors
faculty of applied health sciences technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Age =18 years old • Have been invasively mechanically ventilated via an endotracheal tube for =12 hours • Require a PEEP =10 cmH2O at the time of screening • Are hemodynamically stable with continuous arterial pressure monitoring • Have an indwelling arterial catheter
Exclusion criteria
Exclusion criteria: Hemodynamic instability requiring escalating vasopressors Severe hypoxemia (e.g., PaO2/FiO2 <100 mmHg or SpO2 <90% despite FiO2 =0.6) Pneumothorax, bronchopleural fistula, or active air leak Raised intracranial pressure (contraindication to suctioning) Severe arrhythmias Inability to tolerate suctioning (e.g., severe bronchospasm) Pregnancy Lack of an indwelling arterial line
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •LUS AUC 0–60 min | — |
Secondary
| Measure | Time frame |
|---|---|
| Gas Exchange: PaO2/FiO2 ratio and SpO2 at all timepoints; SpO2 nadir. Arterial blood samples will be analysed at Baseline (mmediately before suctioning), 0 minutes (Immediately after the suction procedure (within 60 seconds), 5, 15, 30, and 60 minutes post-suction.;Respiratory Mechanics: Dynamic compliance and driving pressure.;Safety: Incidence of hypoxemia (SpO230s or 20% drop from baseline), and arrhythmias. ;Recovery: Time for LUS score within 2 points of baseline and PaO2/FiO2 to return to within 5% of baseline. | — |
Countries
Egypt
Contacts
Public Contactzainab a alahajji
respiratory therapist. master degree student
Outcome results
None listed