HIV/AIDS
Conditions
Interventions
Enhanced adherence counselling or motivational interviewing
Basic adherence counselling.
Sponsors
Desmond Tutu Health Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • =16 years old • Signed informed consent for RETAIN at enrolment into SUSTAIN • Enrolled onto the SUSTAIN study (meeting all eligibility criteria) • Flagged as poorly adherent by one of the three study adherence methodolgies • Able to sign written informed consent
Exclusion criteria
Exclusion criteria: • Unable to understand study procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of RETAIN is to explore the more immediate impact of the adherence intervention on individual adherence behaviour through monitoring changes in daily dosing behaviour and drug concentrations (short and long half-life moieties) immediately before and shortly after the intervention is delivered (intra-individual analyses); as well as the immediate impact on viral load. The primary outcomes of RETAIN will include the change in 30-day daily dosing (using Wisepill®) immediately before and within 4 weeks after completion of the adherence intervention; and a change in drug concentrations (plasma tenofovir concentrations, and tenofovir diphosphate from dried blood spot sampling as well as presence of urine tenofovir using a new lateral flow assay) immediately before and within 4 weeks after completion of the adherence intervention (Figure 3 and Tables 1 and 2). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include the impact of the adherence intervention on viral load, as well as retention in care and viral suppression rates at month 12. | — |
Countries
South Africa
Contacts
Public ContactTebogo Joy Mosina
Study coordinator
Outcome results
None listed